Agenda

05 Nov 2021 15:00

Versioning Biological Cells for Trustworthy Cell Engineering

On-line

"Versioning Biological Cells for Trustworthy Cell Engineering​"

Natalio Krasnogor
Professor of Computing Science and Synthetic Biology at Newcastle University and member of the Academic Assembly of the European Centre for Living Technology (ECLT)

5th November 2021, 3 PM CET

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Abstract:

‘Full-stack’ biotechnology platforms for cell line (re)programming are on the horizon, due mostly to (a) advances in gene synthesis and editing techniques as well as (b) the growing integration with informatics, the internet of things and automation. These emerging platforms will accelerate the production and consumption of biological products. Hence, transparency, traceability and -ultimately-trustworthiness is required -from cradle to grave- for engineered cell lines and their engineering processes. I will talk about our efforts to establish the first version control system for cell engineering that integrates a new cloud-based version control software for cell lines’ digital footprint with molecular barcoding of living samples. We argue that version control for cell engineering marks a significant step towards more open, reproducible, easier to trace and share, and more trustworthy engineering biology.‘Full-stack’ biotechnology platforms for cell line (re)programming are on the horizon, due mostly to (a) advances in gene synthesis and editing techniques as well as (b) the growing integration with informatics, the internet of things and automation. These emerging platforms will accelerate the production and consumption of biological products. Hence, transparency, traceability and -ultimately-trustworthiness is required -from cradle to grave- for engineered cell lines and their engineering processes. I will talk about our efforts to establish the first version control system for cell engineering that integrates a new cloud-based version control software for cell lines’ digital footprint with molecular barcoding of living samples. We argue that version control for cell engineering marks a significant step towards more open, reproducible, easier to trace and share, and more trustworthy engineering biology.

Short bio:

Natalio Krasnogor is Professor of Computing Science and Synthetic Biology, directs Newcastle’s Interdisciplinary Computing and Complex BioSystems (ICOS) research group and is director of Newcastle’s Centre for Synthetic Biology and the Bioeconomy (CSBB). Krasnogor holds a prestigious 10 years Chair in Emerging Technologies award from the UK Royal Academy of Science and previously held an EPSRC Leadership Fellowship in Synthetic Biology. Krasnogor is also leading the computational work of the Horizon 2020 “DESTINATION: AI-enabled RNA nanotechnology delivery system for information transfer into cells” project. More generally, Krasnogor works at the interface of Synthetic Biology, DNA/RNA nanotechnology and machine intelligence. He is also interested in the simulation and modeling of complex networks in biological systems.

 

Lingua

L'evento si terrà in inglese

Organizzatore

ECLT European Centre for Living Technology (ECLT)

Link

https://unive.zoom.us/j/89652237775

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