Molecular recognition in asymmetric environment

Research group 

Sergio Antonio Cossu, Associate Professor

Research topics

The research activity is focused on the study of molecular recognition in asymmetric environment. 

Main topics:

  • Recognition mechanisms on polysaccharide-based chiral supports 
  • Halogen bond-driven enantioseparations
  • Synthesis and enantioseparation of  test probes with halogen bond donor (XBD) property 

Recognition mechanisms on polysaccharide-based chiral supports

  1. Peluso, P.; Mamane, V.; Aubert, E.; Cossu, S.
    Recent trends and applications in liquid phase chromatography enantioseparation of atropisomers Electrophoresis 2017, 38, 1830-1850, doi:10.1002/elps.201600502 (invited review on Special Issue Liquid Phase Enantioseparations)
  2. Peluso, P.; Cossu, S.
    Comparative HPLC enantioseparation of thirty six aromatic compounds on four columns of the Lux series. Impact of substituents, shapes and electronic properties
    Chirality 2013, 25, 709-718
  3. Peluso, P.; Fabbri, D.; Dettori, M. A.; Delogu, G.; Zambrano, V.; Cossu, S.
    High-performance liquid chromatographic enantioseparation of atropisomeric biphenyls on seven chiral stationary phases
    Curr. Org. Chem. 2011, 15, 1208-1229
  4. Peluso, P.; Cossu, S.; Moretto, F.; Marchetti, M.
    High performance liquid chromatographic enantioseparation of chiral bridged polycyclic compounds on Chiralcel OD-H and Chiralpak OT(+)
    Chirality 2009, 21, 507-518

Halogen-bond driven enantioseparations

  1. Peluso, P.; Mamane, V.; Aubert, E.; Dessì, A.; Dallocchio, R.; Dore, A.; Pale, P.; Cossu, S.
    Insights into halogen bond-driven enantioseparations
    J. Chromatogr. A 2016, 1467, 228-238 (invited article on Special Issue Enantioseparation 2016)
  2. Peluso, P.; Mamane, V.; Cossu, S.
    LC Enantioseparations of halogenated compounds on polysaccharide-based chiral stationary phases: role of halogen substituents in molecular recognition
    Chirality 2015, 27, 667-684 (invited article on Special Issue Chirality in Separation Science and Molecular Recognition)
  3. Peluso, P.; Mamane, V.; Aubert, E.; Cossu, S.
    Insights into the impact of shape and electronic properties on the enantioseparation of polyhalogenated 4,4’-bipyridines on polysaccharide-type selectors. Evidence of stereoselective halogen bonding interactions
    J. Chromatogr. A 2014, 1345, 182-192

Synthesis and enantioseparation of test probes with halogen bond donor (XBD) property

  1. 1) Mamane, V.; Peluso, P.; Aubert, E.; Cossu, S.; Pale, P.
    Chiral hexahalogenated 4,4’-bipyridines
    J. Org. Chem. 2016, 81, 4576-4587
  2. Peluso, P.; Mamane, V.; Aubert, E.; Cossu, S.
    High-performance liquid chromatography enantioseparation of polyhalogenated 4,4’-bipyridines on polysaccharide-based chiral stationary phases under multimodal elution
    J. Sep. Sci. 2014, 37, 2481-2489
  3. Peluso, P.; Mamane, V.; Aubert, E.; Cossu, S.
    Optimization of the HPLC enantioseparation of 3,3’-dibromo-5,5’-disubstituted-4,4’-bipyridines using immobilized polysaccharide-based chiral stationary phases
    J. Sep. Sci. 2013, 36, 2993-3003
  4. Mamane, V.; Aubert, E.; Peluso, P.; Cossu, S.
    Lithiation of prochiral 2,2’-dichloro-5,5’-dibromo-4,4’-bipyridine as a tool for the synthesis of chiral polyhalogenated 4,4’-bipyridines
    J. Org. Chem. 2013, 78, 7683-7689
  5. Mamane, V.; Aubert, E.; Peluso, P.; Cossu, S.
    Synthesis, resolution, and absolute configuration of chiral 4,4′-bipyridines
    J. Org. Chem. 2012, 77, 2579-2583
  6. Peluso, P.; Mamane, V.; Aubert, E.; Cossu, S.
    High performance liquid chromatography enantioseparation of atropisomeric 4,4’-bipyridines on polysaccharide-type chiral stationary phases: impact of substituents and electronic properties
    J. Chromatogr. A 2012, 1251, 91-100

Last update: 07/07/2020