Bio and Nanotechnology Lab

• Tonon, Giovanni; Rizzolio, Flavio; Visentin, Fabiano; Scattolin, Thomas Antibody Drug Conjugates for Cancer Therapy: From Metallodrugs to Nature-Inspired Payloads in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 25 (ISSN 1422-0067)
• Segato J.; Calmanti R.; Gnoato G.; Cavarzerani E.; Rizzolio F.; Crestini C.; Perosa A.; Gigli M.; Selva M. Fish Scales for Wearable Patches: Tailoring Films Assembled From Fish Waste Gelatin, Carbon Dots and Chitin Nanocrystals in ADVANCED SUSTAINABLE SYSTEMS, vol. 2400413 (ISSN 2366-7486)
• Botter, Eleonora; Caligiuri, Isabella; Rizzolio, Flavio; Visentin, Fabiano; Scattolin, Thomas Liposomal Formulations of Metallodrugs for Cancer Therapy in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 25 (ISSN 1422-0067)
• Muhammad Adeel,Hong Seok Lee, Kanwal Asif, Sabrina Smith, Hasan Kurt, Flavio Rizzolio, Salvatore Daniele, Firat Güder, Micro-Supercapacitors for Self-Powered Biosensors in SMALL SCIENCE, vol. 4, pp. 1-13 (ISSN 2688-4046)
• Sfriso, Andrea Augusto; Juhmani, Abdul-Salam; Tomio, Yari; Sfriso, Adriano; Rizzolio, Flavio; Adeel, Muhammed; Wahsha, Mohammad; Munari, Cristina; Mistri, Michele Microplastic accumulation and ecological impacts on benthic invertebrates: Insights from a microcosm experiment in MARINE POLLUTION BULLETIN, vol. 202 (ISSN 0025-326X)
• Bortolamiol, Enrica; Mauceri, Matteo; Piccolo, Rachele; Cavarzerani, Enrico; Demitri, Nicola; Donati, Chiara; Gandin, Valentina; Brezar, Simona Kranjc; Kamensek, Urska; Cemazar, Maja; Canzonieri, Vincenzo; Rizzolio, Flavio; Visentin, Fabiano; Scattolin, Thomas Palladium(II)-Indenyl Complexes Bearing N-Heterocyclic Carbene (NHC) Ligands as Potent and Selective Metallodrugs toward High-Grade Serous Ovarian Cancer Models in JOURNAL OF MEDICINAL CHEMISTRY, vol. 67, pp. 14414-14431 (ISSN 0022-2623)
• Compagno, Nicola; Piccolo, Rachele; Bortolamiol, Enrica; Demitri, Nicola; Rizzolio, Flavio; Visentin, Fabiano; Scattolin, Thomas Platinum(0)-η2-1,2-(E)ditosylethene Complexes Bearing Phosphine, Isocyanide and N-Heterocyclic Carbene Ligands: Synthesis and Cytotoxicity towards Ovarian and Breast Cancer Cells in MOLECULES, vol. 29 (ISSN 1420-3049)
• Bortolamiol, Enrica; Botter, Eleonora; Cavarzerani, Enrico; Mauceri, Matteo; Demitri, Nicola; Rizzolio, Flavio; Visentin, Fabiano; Scattolin, Thomas Rational Design of Palladium(II) Indenyl and Allyl Complexes Bearing Phosphine and Isocyanide Ancillary Ligands with Promising Antitumor Activity in MOLECULES, vol. 29 (ISSN 1420-3049)
• Scattolin, Thomas; Tonon, Giovanni; Botter, Eleonora; Canale, Viviana Claudia; Hasanzadeh, Mahdi; Cuscela, Denise Maria; Buschini, Annamaria; Zarepour, Atefeh; Khosravi, Arezoo; Cordani, Marco; Rizzolio, Flavio; Zarrabi, Ali Synergistic applications of cyclodextrin-based systems and metal–organic frameworks in transdermal drug delivery for skin cancer therapy in JOURNAL OF MATERIALS CHEMISTRY. B, vol. 12, pp. 3807-3839 (ISSN 2050-7518)
• Scattolin, Thomas; Mauceri, Matteo; Demitri, Nicola; Rizzolio, Flavio; Visentin, Fabiano Synthesis and Anticancer Activity of Palladium‐Butadienyl Complexes Bearing Picolyl‐NHC and Phosphine Ligands in EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, vol. 27 (ISSN 1434-1948)
• Bortolamiol, Enrica; Dalla Pozza, Maria; Demitri, Nicola; Rizzolio, Flavio; Visentin, Fabiano; Gasser, Gilles; Scattolin, Thomas Synthesis and Anticancer Properties of Heterobimetallic Fe(II)/Pd(II) Complexes Bearing Different Butadienyl Fragments in EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, vol. 27 (ISSN 1434-1948)
• Saorin, Asia; Martinez-Serra, Alberto; Paparoni-Bruzual, Germán Jose; Crozzolin, Michele; Lombardi, Vincenzo; Back, Michele; Riello, Pietro; Monopoli, Marco P.; Rizzolio, Flavio Understanding the impact of silica nanoparticles in cancer cells through physicochemical and biomolecular characterizations in MATERIALS ADVANCES, vol. 5, pp. 5106-5117 (ISSN 2633-5409)
• Tonon, Giovanni; Mauceri, Matteo; Cavarzerani, Enrico; Piccolo, Rachele; Santo, Claudio; Demitri, Nicola; Orian, Laura; Nogara, Pablo A.; Rocha, João Batista T.; Canzonieri, Vincenzo; Rizzolio, Flavio; Visentin, Fabiano; Scattolin, Thomas Unveiling the promising anticancer activity of palladium(ii)–aryl complexes bearing diphosphine ligands: a structure–activity relationship analysis in DALTON TRANSACTIONS, vol. 53, pp. 8463-8477 (ISSN 1477-9226)

• Cavarzerani, Enrico; Caligiuri, Isabella; Bartoletti, Michele; Canzonieri, Vincenzo; Rizzolio, Flavio 3D dynamic cultures of HGSOC organoids to model innovative and standard therapies in FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, vol. 11, pp. 1135374 (ISSN 2296-4185)
• Pezzotti, Giuseppe; Adachi, Tetsuya; Imamura, Hayata; Bristol, Davide Redolfi; Adachi, Keiji; Yamamoto, Toshiro; Kanamura, Narisato; Marin, Elia; Zhu, Wenliang; Kawai, Toshihisa; Mazda, Osam; Kariu, Toru; Waku, Tomonori; Nichols, Frank C.; Riello, Pietro; Rizzolio, Flavio; Limongi, Tania; Okuma, Kazu In Situ Raman Study of Neurodegenerated Human Neuroblastoma Cells Exposed to Outer-Membrane Vesicles Isolated from Porphyromonas gingivalis in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 24, pp. 13351 (ISSN 1422-0067)
• Bortolamiol, E; Isetta, G; Caligiuri, I; Demitri, N; Paganelli, S; Rizzolio, F; Scattolin, T; Visentin, F Biological and Catalytic Applications of Pd(II)-Indenyl Complexes Bearing Phosphine and N-Heterocyclic Carbene Ligands in EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, vol. 26 (ISSN 1434-1948)
• Asif, K.; Adeel, M.; Rahman, Md M.; Caligiuri, I.; Perin, Ti.; Cemazar, M.; Canzonieri, V.; Rizzolio, F. Iron nitroprusside as a chemodynamic agent and inducer of ferroptosis for ovarian cancer therapy in JOURNAL OF MATERIALS CHEMISTRY. B, vol. 11 (ISSN 2050-7518)
• Saorin, G.; Caligiuri, I.; Rizzolio, F. Microfluidic organoids-on-a-chip: The future of human models in SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, vol. 144, pp. 41-54 (ISSN 1096-3634)
• Cheraghali, S.; Dini, G.; Caligiuri, I.; Back, M.; Rizzolio, F. PEG-Coated MnZn Ferrite Nanoparticles with Hierarchical Structure as MRI Contrast Agent in NANOMATERIALS, vol. 13, pp. 452 (ISSN 2079-4991)
• Asif, K.; Adeel, M.; Rahman, Md M.; Sfriso, A. A.; Bartoletti, M.; Canzonieri, V.; Rizzolio, F.; Caligiuri, I. Silver nitroprusside as an efficient chemodynamic therapeutic agent and a peroxynitrite nanogenerator for targeted cancer therapies in JOURNAL OF ADVANCED RESEARCH, vol. in press (ISSN 2090-1232)
• Jesenko, T.; Brezar, S. K.; Cemazar, M.; Biasin, A.; Tierno, D.; Scaggiante, B.; Grassi, M.; Grassi, C.; Dapas, B.; Truong, N. H.; Abrami, M.; Zanconati, F.; Bonazza, D.; Rizzolio, F.; Parisi, S.; Pastorin, G.; Grassi, G.: Targeting Non-Coding RNAs for the Development of Novel Hepatocellular Carcinoma Therapeutic Approaches in PHARMACEUTICS, vol. 15, pp. 1249 (ISSN 1999-4923)
• Caligiuri, I.; Canzonieri V.; Asano, T.; Kumar, V.; Rizzolio, F. The metabolic crosstalk between PIN1 and the tumour microenvironment in SEMINARS IN CANCER BIOLOGY, vol. 91, pp. 143-157 (ISSN 1044-579X)

• Scattolin T.; Pessotto I.; Cavarzerani E.; Canzonieri V.; Orian L.; Demitri N.; Schmidt C.; Casini A.; Bortolamiol E.; Visentin F.; Rizzolio F.; Nolan S. P. Indenyl and Allyl Palladate Complexes Bearing N-Heterocyclic Carbene Ligands: an Easily Accessible Class of New Anticancer Drug Candidates in EUROPEAN JOURNAL OF INORGANIC CHEMISTRY – Volume 2022, Issue 16, 8 June 2022 (ISSN 14341948)
• Vianello C.; Cocetta V.; Catanzaro D.; Dorn II G.W.; De Milito A.; Rizzolio F.; Canzonieri V.; Cecchin E.; Roncato R.; Toffoli G.; Quagliariello V.; Di Mauro A.; Losito S.; Maurea N.; Cono S.; Sales G.; Scorrano L.; Giacomello M.; Montopoli M. Correction: Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy in CELL DEATH & DISEASE 2022 (13) (ISSN20414889)
• Cazzaniga, G.; Mori, M.; Meneghetti, F.; Chiarelli, L. ; Stelitano, G.; Caligiuri, I.; Rizzolio, F.; Ciceri, S.; Poli, G.; Staver, D.; Ortore, G.;Tuccinardi, T. Virtual screening and crystallographic studies reveal an unexpected γ-lactone derivative active against MptpB as a potential antitubercular agent in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2022 (ISSN 02235234).
• Palazzolo, S.; Canzonieri, V.; Rizzolio, F. The history of small extracellular vesicles and their implication in cancer drug resistance in FRONTIERS IN ONCOLOGY, vol. 12, pp. 948843 (ISSN 2234-943X)
• Bononi, G.; Di Stefano, M.; Poli, G.; Ortore, G.; Meier, P.; Masetto, F.; Caligiuri, I.; Rizzolio, F.; Macchia, M.; Chicca, A.; Avan, A.; Giovannetti, E.; Vagaggini, C.; Brai, A.; Dreassi, E.; Valoti, M.; Minutolo, F.; Granchi, C.; Gertsch, J.; Tuccinardi, T. Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives in JOURNAL OF MEDICINAL CHEMISTRY, vol. 65, pp. 7118-7140 (ISSN 0022-2623)
• Losurdo, P.; de Manzini, N.; Palmisano, S.; Grassi, M.; Parisi, S.; Rizzolio, F.; Tierno, D.; Biasin, A.; Grassi, C.; Truong, Nhung H.; Grassi, G. Potential Application of Small Interfering RNA in Gastro-Intestinal Tumors in PHARMACEUTICALS, vol. 15, pp. 1295 (ISSN 1424-8247)
• Di Stefano, M.; Galati, S.; Ortore, G.; Caligiuri, I.; Rizzolio, F.; Ceni, C.; Bertini, S.; Bononi, G.; Granchi, C.; Macchia, M.; Poli, G.; Tuccinardi, T. Machine Learning-Based Virtual Screening for the Identification of Cdk5 Inhibitors in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, pp. 10653 (ISSN 1422-0067)
• Martynova, E. A; Scattolin, T.; Cavarzerani, E.; Peng, M.; Van Hecke, K.; Rizzolio, F.; Nolan, S. P. A simple synthetic entryway into new families of NHC-gold-amido complexes and their in vitro antitumor activity in DALTON TRANSACTIONS 2022 (ISSN 14779226).
• Palazzolo, S.; Caligiuri, I.;Sfriso, A. A.;Mauceri, M.; Rotondo, R.; Campagnol, D.; Canzonieri, V.; Rizzolio, F. Early Warnings by Liver Organoids on Short-and Long-Chain PFAS Toxicity in TOXICS 2022 vol. 10, pp. 91 (ISSN 2305-6304) (ISSN 23056304)
• Ortore, G.; Poli, G.; Martinelli, A.; Tuccinardi, T.; Rizzolio, F.; Caligiuri, I. From Anti-Infective Agents to Cancer Therapy: A Drug Repositioning Study Revealed a New Use for Nitrofuran Derivatives in MEDICINAL CHEMISTRY 2022 18(2), pp. 249–259 (ISSN 15734064).
• Tzouras, N.V.; Scattolin, T.; Gobbo, A.; Bhandary, S.; Rizzolio, F.; Cavarzerani, E.; Canzonieri, V.; Van Hecke, K.; Vougioukalakis, G. C.; Cazin, C. S. J.; Nolan, S.P. A Green Synthesis of Carbene-Metal-Amides (CMAs) and Carboline-Derived CMAs with Potent in vitro and ex vivo Anticancer Activity in ChemMedChem 2022 (ISSN 18607179)
• Adeel M.; Saorin G.; Boccalon G.; Sfriso A.A.; Parisi S.; Moro I.; Palazzolo S.; Caligiuri I.; Granchi C.; Corona G.; Cemazar M.; Canzonieri V.; Tuccinardi T.; Rizzolio F. A carrier free delivery system of a monoacylglycerol lipase hydrophobic inhibitor in INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 613, pp. 121374 (ISSN 0378-5173)
• Adeel M.; Asif K.; Canzonieri V.; Barai H.R.; Rahman M.M.; Daniele S.; Rizzolio F. Controlled, partially exfoliated, self-supported functionalized flexible graphitic carbon foil for ultrasensitive detection of SARS-CoV-2 spike protein in SENSORS AND ACTUATORS. B, CHEMICAL, vol. 359, pp. 131591 (ISSN 0925-4005)
• Poli G.; Di Stefano M.; Estevez J.A.; Minutolo F.; Granchi C.; Giordano A.; Parisi S.; Mauceri M.; Canzonieri V.; Macchia M.; Caligiuri I.; Tuccinardi T.; Rizzolio F. New PIN1 inhibitors identified through a pharmacophore-driven, hierarchical consensus docking strategy in JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 145-150 (ISSN 1475-6366)
• Scuto M.; Ontario M.L.; Salinaro A.T.; Caligiuri I.; Rampulla F.; Zimbone V.; Modafferi S.; Rizzolio F.; Canzonieri V.; Calabrese E.J.; Calabrese V. Redox modulation by plant polyphenols targeting vitagenes for chemoprevention and therapy: Relevance to novel anti-cancer interventions and mini-brain organoid technology in FREE RADICAL BIOLOGY & MEDICINE, vol. 179, pp. 59-75 (ISSN 0891-5849)
• Scattolin T.; Moro G.; Serena A.; Guadagnin Pattaro A.; Rizzolio F.; Canzonieri V.; Demitri N.; Bortolamiol E.; Moretto L.M.; Visentin F. Synthesis, characterization, and anticancer activity of ferrocenyl complexes bearing different organopalladium fragments in APPLIED ORGANOMETALLIC CHEMISTRY, vol. e6629 (ISSN 0268-2605)
• Bortolamiol E., Fama F., Zhang Z., Demitri N., Cavallo L., Caligiuri I., Rizzolio F., Scattolin T., Visentin F., Cationic palladium(II)-indenyl complexes bearing phosphines as ancillary ligands: synthesis, and study of indenyl amination and anticancer activity in DALTON TRANSACTIONS, vol. 51, pp. 11135-11151 (ISSN 1477-9226)
• Adeel M., Asif K., Alshabouna F., Canzonieri V. Md., Rahman M., Ansari S.A., Güder F., Rizzolio F., Daniele S. Label-free electrochemical aptasensor for the detection of SARS-CoV-2 spike protein based on carbon cloth sputtered gold nanoparticles in BIOSENSORS AND BIOELECTRONICS. X, vol. 12, pp. 1-9 (ISSN 2590-1370)
• Campagnol D., Karimian N., Paladin D., Rizzolio F., Ugo P. Molecularly imprinted electrochemical sensor for the ultrasensitive detection of cytochrome c in BIOELECTROCHEMISTRY, vol. 148, pp. 108269-108276 (ISSN 1567-5394)

• Adeel, M., Canzonieri, V., Daniele, S., Rizzolio, F., Organobase assisted synthesis of Co(OH)2 nanosheets enriched with oxygen vacancies for nanoenzymatic glucose sensing at physiological pH Rahman, M.M. Journal of Industrial and Engineering Chemistry, 2021, 103, pp. 165–174
• Bononi, G., Tonarini, G., Poli, G., …Granchi, C., Tuccinardi,Monoacylglycerol lipase (MAGL) inhibitors based on a diphenylsulfide-benzoylpiperidine scaffold T.European Journal of Medicinal Chemistry, 2021, 223, 113679
• Scattolin, T., Andreetta, G., Mauceri, M., …Canzonieri, V., Visentin,Imidazo[1,5-a]pyridine-3-ylidenes and dipyridoimidazolinylidenes as ancillary ligands in Palladium allyl complexes with potent in vitro anticancer activity F.Journal of Organometallic Chemistry, 2021, 952, 122014
• Scuto, M., Trovato Salinaro, A., Caligiuri, I., …Canzonieri, V., Calabrese, V. Redox modulation of vitagenes via plant polyphenols and vitamin D: Novel insights for chemoprevention and therapeutic interventions based on organoid technologyMechanisms of Ageing and Development, 2021, 199, 111551
• Scattolin, T., Piccin, A., Mauceri, M., Rizzolio F., Demitri N., Canzonieri, V., Visentin, F. Synthesis, characterization and anticancer activity of palladium allyl complexes bearing benzimidazole-based N-heterocyclic carbene (NHC) ligands Polyhedron, 2021, 207, 115381
• Bayda, S., Amadio, E., Cailotto, S., Frion Herrera Y., Perosa, A., Rizzolio, F. Carbon dots for cancer nanomedicine: a bright future Nanoscale Advances, 2021, 3(18), pp. 5183–5221
• Asif, K., Memeo, L., Palazzolo, S., Frion Herrera Y., Parisi S., Caligiuri I., Canzonieri V., Granchi C., Tuccinardi, T., Rizzolio, F. Stard3: A prospective target for cancer therapy Cancers, 2021, 13(18), 4693
• Morandini A., Spadati E., Leonetti B., Sole R., Gatto V., Rizzolio F., Beghetto V. Sustainable triazine-derived quaternary ammonium salts as antimicrobial agentsRSC Advances, 2021, 11(45), pp. 28092–28096
• Tonon F., Farra R., Zennaro C., Pozzato G., Truong N., Parisi S., Rizzolio F., Grassi G., Dapas B. Xenograft zebrafish models for the development of novel anti-hepatocellular carcinoma molecules Pharmaceuticals, 2021, 14(8), 803
• Memeo, L., Canzonieri, V., Rizzolio, F. Cancer organoids in basic science and translational medicine Cancers, 2021, 13(15), 3701
• Bononi, G., Tuccinardi, T., Rizzolio, F., Granchi, C. α/β-Hydrolase Domain (ABHD) Inhibitors as New Potential Therapeutic Options against Lipid-Related Diseases Journal of Medicinal Chemistry, 2021, 64(14), pp. 9759–9785
• Biscaglia, F., Caligiuri, I., Rizzolio, F., Ripani G., Palleschi A., Meneghetti, M., Gobbo, M. Protection against proteolysis of a targeting peptide on gold nanostructures Nanoscale, 2021, 13(23), pp. 10544–10554
• Adeel, M., Canzonieri, V., Daniele, S., Vomiero A., Rizzolio, F., Rahman, M.M. 2D metal azolate framework as nanozyme for amperometric detection of glucose at physiological pH and alkaline medium. Microchimica Acta, 2021, 188(3), 77
• Duzagac, F., Saorin, G., Memeo, L., Canzonieri, V., Rizzolio, Microfluidic organoids‐on‐a‐chip: Quantum leap in cancer research F. Cancers, 2021, 13(4), pp. 1–35, 737
• Adeel, M., Asif, K., Rahman M. Md, Daniele S., Canzonieri, V., Rizzolio, F. Glucose Detection Devices and Methods Based on Metal–Organic Frameworks and Related Materials Advanced Functional Materials, 2021
• Morandini, A., Leonetti, B., Riello, P., Sole R., Gatto V., Caligiuri I., Rizzolio, F., Beghetto, V. Synthesis and Antimicrobial Evaluation of Bis-morpholine Triazine Quaternary Ammonium Salts ChemMedChem, 2021
• Bononi, G., Poli, G., Rizzolio, F., Tuccinardi T., Macchia M., Minutolo, F., Granchi, C. An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present) Expert Opinion on Therapeutic Patents, 2021, 31(2), pp. 153–168
• Granchi, C., Bononi, G., Ferrisi, R.,Gori E., Mantini G., Glasmacher S., Poli G., Palazzolo S., Caligiuri I., Rizzolio F., Canzonieri V., Perin T., Gertsch J., Sodi A., Giovannetti E., Macchia M., Minutolo F., Tuccinardi, T., Chicca, A. Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors European Journal of Medicinal Chemistry, 2021, 209, 112857
• Jha, V., Galati, S., Volpi, V., Ciccone L., Minutolo F., Rizzolio F., Granchi C., Poli, G., Tuccinardi, T. Discovery of a new ATP-citrate lyase (ACLY) inhibitor identified by a pharmacophore-based virtual screening study Journal of Biomolecular Structure and Dynamics, 2021, 39(11), pp. 3996–4004

2020

• Scattolin T.; Bortolamiol E.; Rizzolio F.; Demitri N.; Visentin F. Allyl palladium complexes bearing carbohydrate-based N-heterocyclic carbenes: Anticancer agents for selective and potent in vitro cytotoxicity in APPLIED ORGANOMETALLIC CHEMISTRY, vol. 34 (ISSN 0268-2605) Link DOI Link al documento: 10278/3729872
• Bononi G.; Poli G.; Rizzolio F.; Tuccinardi T.; Macchia M.; Minutolo F.; Granchi C. An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present) in EXPERT OPINION ON THERAPEUTIC PATENTS, vol. NA, pp. 1-16-16 (ISSN 1354-3776) Link DOI Link al documento: 10278/3735589
• Poli G.; Granchi C.; Rizzolio F.; Tuccinardi T. Application of MM-PBSA methods in virtual screening in MOLECULES, vol. 25, pp. 1971 (ISSN 1420-3049) Link DOI Link al documento: 10278/3735588
• Palazzolo S.; Memeo L.; Hadla M.; Duzagac F.; Steffan A.; Perin T.; Canzonieri V.; Tuccinardi T.; Caligiuri I.; Rizzolio F. Cancer extracellular vesicles: Next-generation diagnostic and drug delivery nanotools in CANCERS, vol. 12, pp. 1-36 (ISSN 2072-6694)Link DOI Link al documento: 10278/3735598
• Jha V.; Galati S.; Volpi V.; Ciccone L.; Minutolo F.; Rizzolio F.; Granchi C.; Poli G.; Tuccinardi T. Discovery of a new ATP-citrate lyase (ACLY) inhibitor identified by a pharmacophore-based virtual screening study in JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, vol. NA, pp. 1-9-9 (ISSN 0739-1102) Link DOI Link al documento: 10278/3735590
• Lepeltier E.; Rijo P.; Rizzolio F.; Popovtzer R.; Petrikaite V.; Assaraf Y.G.; Passirani C. Nanomedicine to target multidrug resistant tumors in DRUG RESISTANCE UPDATES, vol. 52, pp. 100704 (ISSN 1368-7646) Link DOI Link al documento: 10278/3735593
• Scattolin T.; Bortolamiol E.; Visentin F.; Palazzolo S.; Caligiuri I.; Perin T.; Canzonieri V.; Demitri N.; Rizzolio F.; Togni A. Palladium(II)-η3-Allyl Complexes Bearing N-Trifluoromethyl N-Heterocyclic Carbenes: A New Generation of Anticancer Agents that Restrain the Growth of High-Grade Serous Ovarian Cancer Tumoroids in CHEMISTRY-A EUROPEAN JOURNAL, vol. 26, pp. 11868-11876 (ISSN 0947-6539) Link DOI Link al documento: 10278/3729870
• Adeel M.; Rahman M.M.; Caligiuri I.; Canzonieri V.; Rizzolio F.; Daniele S. Recent advances of electrochemical and optical enzyme-free glucose sensors operating at physiological conditions in BIOSENSORS & BIOELECTRONICS, vol. 165, pp. 112331 (ISSN 0956-5663) Link DOI Link al documento: 10278/3733238
• Dinic J.; Efferth T.; Garcia-Sosa A.T.; Grahovac J.; Padron J.M.; Pajeva I.; Rizzolio F.; Saponara S.; Spengler G.; Tsakovska I. Repurposing old drugs to fight multidrug resistant cancers in DRUG RESISTANCE UPDATES, vol. 52, pp. 100713 (ISSN 1368-7646) Link DOI Link al documento: 10278/3735587
• Adeel M.; Duzagac F.; Canzonieri V.; Rizzolio F. Self-Therapeutic Nanomaterials for Cancer Therapy: A Review in ACS APPLIED NANO MATERIALS, vol. 3, pp. 4962-4971 (ISSN 2574-0970) Link DOI Link al documento: 10278/3733239
• Campalani, Carlotta; Chioggia, Francesco; Amadio, Emanuele; Gallo, Michele; Rizzolio, Flavio; Selva, Maurizio; Perosa, Alvise Supercritical CO2 extraction of natural antibacterials from low value weeds and agro-waste in JOURNAL OF CO2 UTILIZATION, vol. 40, pp. 101198 (ISSN 2212-9820) Link DOI Link al documento: 10278/3726542
• Scattolin T.; Bortolamiol E.; Caligiuri I.; Rizzolio F.; Demitri N.; Visentin F. Synthesis and comparative study of the anticancer activity of η3-allyl palladium(II) complexes bearing N-heterocyclic carbenes as ancillary ligands in POLYHEDRON, vol. 186, pp. 114607 (ISSN 0277-5387)Link DOI Link al documento: 10278/3728813
• Velihina Y.; Scattolin T.; Bondar D.; Pil’o S.; Obernikhina N.; Kachkovskyi O.; Semenyuta I.; Caligiuri I.; Rizzolio F.; Brovarets V.; Karpichev Y.; Nolan S.P. Synthesis, in silico and in vitro Evaluation of Novel Oxazolopyrimidines as Promising Anticancer Agents in HELVETICA CHIMICA ACTA, vol. 103 (ISSN 0018-019X) Link DOI Link al documento: 10278/3735594
• Scattolin T.; Bortolamiol E.; Palazzolo S.; Caligiuri I.; Perin T.; Canzonieri V.; Demitri N.; Rizzolio F.; Cavallo L.; Dereli B.; Mane M.V.; Nolan S.P.; Visentin F. The anticancer activity of an air-stable Pd(i)-NHC (NHC = N-heterocyclic carbene) dimer in CHEMICAL COMMUNICATIONS, vol. 56, pp. 12238-12241 (ISSN 1359-7345) Link DOI Link al documento: 10278/3731346
• Bayda S.; Adeel M.; Tuccinardi T.; Cordani M.; Rizzolio F. The history of nanoscience and nanotechnology: From chemical-physical applications to nanomedicine in MOLECULES, vol. 25, pp. 112 (ISSN 1420-3049) Link DOI Link al documento: 10278/3733241
• Casagrande E.; Back M.; Cristofori D.; Ueda J.; Tanabe S.; Palazzolo S.; Rizzolio F.; Canzonieri V.; Trave E.; Riello P. Upconversion-mediated Boltzmann thermometry in double-layered Bi2SiO5:Yb3+,Tm3+@SiO2hollow nanoparticles in JOURNAL OF MATERIALS CHEMISTRY. C, vol. 8, pp. 7828-7836 (ISSN 2050-7534) Link DOI Link al documento: 10278/3728414

2019

• Bayda S, Adeel M, Tuccinardi T, Cordani M, Rizzolio F. The History of Nanoscience and Nanotechnology: From Chemical-Physical Applications to Nanomedicine. Molecules. 2019 Dec 27;25(1):112. doi: 10.3390/molecules25010112. PMID: 31892180
• Palazzolo S, Hadla M, Russo Spena C, Caligiuri I, Rotondo R, Adeel M, Kumar V, Corona G, Canzonieri V, Toffoli G, Rizzolio F. An Effective Multi-Stage Liposomal DNA Origami Nanosystem for In Vivo Cancer Therapy. Cancers (Basel). 2019 Dec 12;11(12):1997. doi: 10.3390/cancers11121997. PMID: 31842277
• Chiarelli LR, Mori M, Beretta G, Gelain A, Pini E, Sammartino JC, Stelitano G, Barlocco D, Costantino L, Lapillo M, Poli G, Caligiuri I, Rizzolio F, Bellinzoni M, Tuccinardi T, Villa S, Meneghetti F. New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents. J Enzyme Inhib Med Chem. 2019 Dec;34(1):823-828. doi: 10.1080/14756366.2019.1589462. PMID: 30889995
• Poli G, Lapillo M, Jha V, Mouawad N, Caligiuri I, Macchia M, Minutolo F, Rizzolio F, Tuccinardi T, Granchi C. Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors. J Enzyme Inhib Med Chem. 2019 Dec;34(1):589-596. doi: 10.1080/14756366.2019.1571271. PMID: 30696302
• Farra R, Maruna M, Perrone F, Grassi M, Benedetti F, Maddaloni M, El Boustani M, Parisi S, Rizzolio F, Forte G, Zanconati F, Cemazar M, Kamensek U, Dapas B, Grassi G. Strategies for Delivery of siRNAs to Ovarian Cancer Cells. Pharmaceutics. 2019 Oct 22;11(10). pii: E547. doi: 10.3390/pharmaceutics11100547. Review. PMID: 31652539
• Tuccinardi T, Rizzolio F. Editorial: Peptidyl-Prolyl Isomerases in Human Pathologies. Front Pharmacol. 2019 Jul 11;10:794. doi: 10.3389/fphar.2019.00794. eCollection 2019. No abstract available. PMID: 31354501
• Chiarelli LR, Mori M, Beretta G, Gelain A, Pini E, Sammartino JC, Stelitano G, Barlocco D, Costantino L, Lapillo M, Poli G, Caligiuri I, Rizzolio F, Bellinzoni M, Tuccinardi T, Villa S, Meneghetti F. New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents. J Enzyme Inhib Med Chem. 2019 Dec;34(1):823-828. doi: 10.1080/14756366.2019.1589462. PMID: 30889995
• Lapillo M, Salis B, Palazzolo S, Poli G, Granchi C, Minutolo F, Rotondo R, Caligiuri I, Canzonieri V, Tuccinardi T, Rizzolio F. First-of-its-kind STARD3 Inhibitor: In Silico Identification and Biological Evaluation as Anticancer Agent. ACS Med Chem Lett. 2019 Feb 20;10(4):475-480. doi: 10.1021/acsmedchemlett.8b00509. eCollection 2019 Apr 11. PMID: 30996782
• Poli G, Lapillo M, Jha V, Mouawad N, Caligiuri I, Macchia M, Minutolo F, Rizzolio F, Tuccinardi T, Granchi C. Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors. J Enzyme Inhib Med Chem. 2019 Dec;34(1):589-596. doi: 10.1080/14756366.2019.1571271. PMID: 30696302
• Granchi C, Lapillo M, Glasmacher S, Bononi G, Licari C, Poli G, El Boustani M, Caligiuri I, Rizzolio F, Gertsch J, Macchia M, Minutolo F, Tuccinardi T, Chicca A. Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor. J Med Chem. 2019 Feb 28;62(4):1932-1958. doi: 10.1021/acs.jmedchem.8b01483. Epub 2019 Feb 11. PMID: 30715876
• Russo Spena C, De Stefano L, Poli G, Granchi C, El Boustani M, Ecca F, Grassi G, Grassi M, Canzonieri V, Giordano A, Tuccinardi T, Caligiuri I, Rizzolio F. Virtual screening identifies a PIN1 inhibitor with possible antiovarian cancer effects. J Cell Physiol. 2019 Jan 29. doi: 10.1002/jcp.28224. [Epub ahead of print] PMID: 30697729
• Palazzolo S, Hadla M, Spena CR, Bayda S, Kumar V, Lo Re F, Adeel M, Caligiuri I, Romano F, Corona G, Canzonieri V, Toffoli G, Rizzolio F. Proof-of-Concept Multistage Biomimetic Liposomal DNA Origami Nanosystem for the Remote Loading of Doxorubicin. ACS Med Chem Lett. 2019 Jan 31;10(4):517-521. doi: 10.1021/acsmedchemlett.8b00557. eCollection 2019 Apr 11. PMID:30996789
• Scattolin T, Caligiuri I, Mouawad N, El Boustani M, Demitri N, Rizzolio F, Visentin F. Synthesis and in-depth studies on the anticancer activity of novel palladacyclopentadienyl complexes stabilized by N-Heterocyclic carbene ligands. Eur J Med Chem. 2019 Oct 1;179:325-334. doi: 10.1016/j.ejmech.2019.06.065. Epub 2019 Jun 22. PMID: 31255929

2018

• Rizzolio F. Nanomedicine in Cancer Pathology. Curr Med Chem. 2018;25(34):4190-4191. doi: 10.2174/092986732534181026111151. PMID: 30563443
• El Boustani M, De Stefano L, Caligiuri I, Mouawad N, Granchi C, Canzonieri V, Tuccinardi T, Giordano A, Rizzolio F. A Guide to PIN1 Function and Mutations Across Cancers. Front Pharmacol. 2019 Jan 22;9:1477. doi: 10.3389/fphar.2018.01477. eCollection 2018. PMID: 30723410
• Poli G, Lapillo M, Granchi C, Caciolla J, Mouawad N, Caligiuri I, Rizzolio F, Langer T, Minutolo F, Tuccinardi T. Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors. J Enzyme Inhib Med Chem. 2018 Dec;33(1):956-961. doi: 10.1080/14756366.2018.1469017. PMID: 29747534
• Scattolin T, Caligiuri I, Canovese L, Demitri N, Gambari R, Lampronti I, Rizzolio F, Santo C, Visentin F. Synthesis of new allyl palladium complexes bearing purine-based NHC ligands with antiproliferative and proapoptotic activities on human ovarian cancer cell lines. Dalton Trans. 2018 Oct 2;47(38):13616-13630. doi: 10.1039/c8dt01831f.PMID: 30207339
• Bononi G, Granchi C, Lapillo M, Giannotti M, Nieri D, Fortunato S, Boustani ME, Caligiuri I, Poli G, Carlson KE, Kim SH, Macchia M, Martinelli A, Rizzolio F, Chicca A, Katzenellenbogen JA, Minutolo F, Tuccinardi T. Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors. Eur J Med Chem. 2018 Sep 5;157:817-836. doi: 10.1016/j.ejmech.2018.08.038. Epub 2018 Aug 16. PMID: 30144699
• Piccoli M, D’Angelo E, Crotti S, Sensi F, Urbani L, Maghin E, Burns A, De Coppi P, Fassan M, Rugge M, Rizzolio F, Giordano A, Pilati P, Mammano E, Pucciarelli S, Agostini M. Decellularized colorectal cancer matrix as bioactive microenvironment for in vitro 3D cancer research. J Cell Physiol. 2018 Aug;233(8):5937-5948. doi: 10.1002/jcp.26403. Epub 2018 Feb 27. PMID: 29244195
• Cailotto S, Amadio E, Facchin M, Selva M, Pontoglio E, Rizzolio F, Riello P, Toffoli G, Benedetti A, Perosa A. Carbon Dots from Sugars and Ascorbic Acid: Role of the Precursors on Morphology, Properties, Toxicity, and Drug Uptake. ACS Med Chem Lett. 2018 Jul 16;9(8):832-837. doi: 10.1021/acsmedchemlett.8b00240. eCollection 2018 Aug 9. PMID: 30128076
• Russo Spena C, De Stefano L, Palazzolo S, Salis B, Granchi C, Minutolo F, Tuccinardi T, Fratamico R, Crotti S, D’Aronco S, Agostini M, Corona G, Caligiuri I, Canzonieri V, Rizzolio F. Liposomal delivery of a Pin1 inhibitor complexed with cyclodextrins as new therapy for high-grade serous ovarian cancer. J Control Release. 2018 Jul 10;281:1-10. doi: 10.1016/j.jconrel.2018.04.055. Epub 2018 May 8. PMID: 29746956
• Farra R, Musiani F, Perrone F, Čemažar M, Kamenšek U, Tonon F, Abrami M, Ručigaj A, Grassi M, Pozzato G, Bonazza D, Zanconati F, Forte G, El Boustani M, Scarabel L, Garziera M, Russo Spena C, De Stefano L, Salis B, Toffoli G, Rizzolio F, Grassi G, Dapas B. Polymer-Mediated Delivery of siRNAs to Hepatocellular Carcinoma: Variables Affecting Specificity and Effectiveness. Molecules. 2018 Mar 28;23(4). pii: E777. doi: 10.3390/molecules23040777. Review. PMID: 29597300
• Aghazadeh Tabrizi M, Baraldi PG, Baraldi S, Ruggiero E, De Stefano L, Rizzolio F, Di Cesare Mannelli L, Ghelardini C, Chicca A, Lapillo M, Gertsch J, Manera C, Macchia M, Martinelli A, Granchi C, Minutolo F, Tuccinardi T. Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors. J Med Chem. 2018 Feb 8;61(3):1340-1354. doi: 10.1021/acs.jmedchem.7b01845. Epub 2018 Jan 22. PMID: 29309142
• Dubuc C, Savard M, Bovenzi V, Lessard A, Fortier A, Côté J, Neugebauer W, Rizzolio F, Geha S, Giordano A, Chemtob S, Gobeil F. Targeting intracellular B2 receptors using novel cell-penetrating antagonists to arrest growth and induce apoptosis in human triple-negative breast cancer. Oncotarget. 2018 Jan 5;9(11):9885-9906. doi: 10.18632/oncotarget.24009. eCollection 2018 Feb 9. PMID: 29515778
• Granchi C, Rizzolio F, Caligiuri I, Macchia M, Martinelli A, Minutolo F, Tuccinardi T. Rational Development of MAGL Inhibitors. Methods Mol Biol. 2018;1824:335-346. doi: 10.1007/978-1-4939-8630-9_20. PMID: 30039417

2017

• Bayda S, Hadla M, Palazzolo S, Corona G, Toffoli G, Rizzolio F. Inorganic Nanoparticles for Cancer Therapy: a Transition from Lab to Clinic. Curr Med Chem. 2017 Dec 29. doi: 10.2174/0929867325666171229141156. [Epub ahead of print] PMID: 29284391
• Rani R, Kumar V, Rizzolio F. Fluorescent Carbon Nanoparticles in Medicine for Cancer Therapy: An Update. ACS Med Chem Lett. 2017 Dec 28;9(1):4-5. doi: 10.1021/acsmedchemlett.7b00523. eCollection 2018 Jan 11. PMID: 29348802
• Granchi C, Caligiuri I, Minutolo F, Rizzolio F, Tuccinardi T. A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017). Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. doi: 10.1080/13543776.2018.1389899. Epub 2017 Oct 20. Review. PMID: 29053063
• Granchi C, Caligiuri I, Bertelli E, Poli G, Rizzolio F, Macchia M, Martinelli A, Minutolo F, Tuccinardi T. Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors. J Enzyme Inhib Med Chem. 2017 Dec;32(1):1240-1252. doi: 10.1080/14756366.2017.1375484. PMID: 28936880
• Palazzolo S, Bayda S, Hadla M, Caligiuri I, Corona G, Toffoli G, Rizzolio F. The Clinical translation of Organic Nanomaterials for Cancer Therapy: A Focus on Polymeric Nanoparticles, Micelles, Liposomes and Exosomes. Curr Med Chem. 2017 Aug 29. doi: 10.2174/0929867324666170830113755. [Epub ahead of print]
• Granchi C, Fortunato S, Meini S, Rizzolio F, Caligiuri I, Tuccinardi T, Lee HY, Hergenrother PJ, Minutolo F. Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer. J Agric Food Chem. 2017 Jul 19;65(28):5639-5649. doi: 10.1021/acs.jafc.7b01668. Epub 2017 Jul 7.
• Scarabel L, Perrone F, Garziera M, Farra R, Grassi M, Musiani F, Russo Spena C, Salis B, De Stefano L, Toffoli G, Rizzolio F, Tonon F, Abrami M, Chiarappa G, Pozzato G, Forte G, Grassi G, Dapas B. Strategies to optimize siRNA delivery to hepatocellular carcinoma cells. Expert Opin Drug Deliv. 2017 Jun;14(6):797-810. doi: 10.1080/17425247.2017.1292247. Epub 2017 Feb 17.
• Crotti S, Piccoli M, Rizzolio F, Giordano A, Nitti D, Agostini M. Extracellular Matrix and Colorectal Cancer: How Surrounding Microenvironment Affects Cancer Cell Behavior? J Cell Physiol. 2017 May;232(5):967-975. doi: 10.1002/jcp.25658. Epub 2016 Nov 10. Review.
• Zanusso C, Bortolus R, Dreussi E, Polesel J, Montico M, Cecchin E, Gagno S, Rizzolio F, Arcicasa M, Novara G, Toffoli G. Impact of DNA repair gene polymorphisms on the risk of biochemical recurrence after radiotherapy and overall survival in prostate cancer. Oncotarget. 2017 Apr 4;8(14):22863-22875. doi: 10.18632/oncotarget.15282
• Xu L, Ren Z, Chow FE, Tsai R, Liu T, Rizzolio F, Boffo S, Xu Y, Huang S, Lippa CF, Gong Y. Pathological Role of Peptidyl-Prolyl Isomerase Pin1 in the Disruption of Synaptic Plasticity in Alzheimer’s Disease. Neural Plast. 2017;2017:3270725. doi: 10.1155/2017/3270725. Epub 2017 Mar 26.

2016

• Bayda S, Hadla M, Palazzolo S, Kumar V, Caligiuri I, Ambrosi E, Pontoglio E, Agostini M, Tuccinardi T, Benedetti A, Riello P, Canzonieri V, Corona G, Toffoli G, Rizzolio F. Bottom-Up Synthesis of Carbon Nanoparticles with Higher Doxorubicin Efficacy. J Control Release. 2016 Nov 22. pii: S0168-3659(16)30882-3. doi: 10.1016/j.jconrel.2016.11.022.
• Granchi C, Rizzolio F, Palazzolo S, Carmignani S, Macchia M, Saccomanni G, Manera C, Martinelli A, Minutolo F, Tuccinardi T. Structural optimization of 4-chlorobenzoylpiperidine derivatives for the development of potent, reversible and selective monoacylglycerol lipase (MAGL) inhibitors. J Med Chem. 2016 Nov 3. [Epub ahead of print] PMID: 27809504
• Hadla M, Palazzolo S, Corona G, Caligiuri I, Canzonieri V, Toffoli G, Rizzolio F. Exosomes increase the therapeutic index of doxorubicin in breast and ovarian cancer mouse models. Nanomedicine (Lond). 2016 Sep;11(18):2431-41. doi: 10.2217/nnm-2016-0154. PMID: 27558906
• Pellizzoni E, Tommasini M, Marangon E, Rizzolio F, Saito G, Benedetti F, Toffoli G, Resmini M, Berti F. Fluorescent molecularly imprinted nanogels for the detection of anticancer drugs in human plasma. Biosens Bioelectron. 2016 Dec 15;86:913-9. doi: 10.1016/j.bios.2016.07.087. PMID: 27497198
• Millino C, Maretto I, Pacchioni B, Digito M, De Paoli A, Canzonieri V, D’Angelo E, Agostini M, Rizzolio F, Giordano A, Barina A, Rajendran S, Esposito G, Lanfranchi G, Nitti D, Pucciarelli S. Gene and microRNA Expression Are Predictive of Tumor Response in Rectal Adenocarcinoma Patients Treated with Preoperative Chemoradiotherapy. J Cell Physiol. 2016 May 25. doi: 10.1002/jcp.25441. [Epub ahead of print] PMID: 27225591
• Miolo G, Muraro E, Caruso D, Crivellari D, Ash A, Scalone S, Lombardi D, Rizzolio F, Giordano A, Corona G. Phamacometabolomics study identifies circulating spermidine and tryptophan as potential biomarkers associated with the complete pathological response to trastuzumab-paclitaxel neoadjuvant therapy in HER-2 positive breast cancer. Oncotarget. 2016 May 19. doi: 10.18632/oncotarget.9489. [Epub ahead of print] PMID: 27223427
• Granchi C, Lapillo M, Spena CR, Rizzolio F, Tuccinardi T, Martin TA, Carlson KE, Katzenellenbogen JA, Minutolo F. Cyclic Ketoximes as Estrogen Receptor β Selective Agonists. ChemMedChem. 2016 May 2. doi: 10.1002/cmdc.201600140. [Epub ahead of print] PMID: 27135651
• Kumar V, Palazzolo S, Bayda S, Corona G, Toffoli G, Rizzolio F. DNA Nanotechnology for Cancer Therapy. Theranostics. 2016 Mar 20;6(5):710-25. doi: 10.7150/thno.14203. eCollection 2016. Review. PMID: 27022418
• Kumar V, Bayda S, Hadla M, Caligiuri I, Russo Spena C, Palazzolo S, Kempter S, Corona G, Toffoli G, Rizzolio F. Enhanced Chemotherapeutic Behavior of Open-Caged DNA@Doxorubicin Nanostructures for Cancer Cells. J Cell Physiol. 2016 Jan;231(1):106-10. PMID: 26031628

2015

• Toffoli G, Hadla M, Corona G, Caligiuri I, Palazzolo S, Semeraro S, Gamini A, Canzonieri V, Rizzolio F. Exosomal doxorubicin reduces the cardiac toxicity of doxorubicin. Nanomedicine (Lond). 2015 Sep 30. [Epub ahead of print]. PMID:26420143
• Agostini M, Janssen KP, Kim IJ, D’Angelo E, Pizzini S, Zangrando A, Zanon C, Pastrello C, Maretto I, Digito M, Bedin C, Jurisica I, Rizzolio F, Giordano A, Bortoluzzi S, Nitti D, Pucciarelli S. An integrative approach for the identification of prognostic and predictive biomarkers in rectal cancer. Oncotarget. 2015 Oct 20;6(32):32561-74. PMID: 26359356
• Gabriele Sponchia, Emmanuele Ambrosi, Flavio Rizzolio, Mohamad Hadla, Anna Del Tedesco, Concetta Russo Spena, Giuseppe Toffoli, Pietro Riello and Alvise Benedetti. Biocompatible tailored zirconia mesoporous nanoparticles with high surface area for theranostic applications. J. Mater. Chem. B, 2015,3, 7300-7306. DOI: 10.1039/C5TB01424G
• Bedin C, Crotti S, Ragazzi E, Pucciarelli S, Agatea L, Tasciotti E, Ferrari M, Traldi P, Rizzolio F, Giordano A, Nitti D, Agostini M. Alterations of the Plasma Peptidome Profiling in Colorectal Cancer Progression. J Cell Physiol. 2015 Sep 17. PMID:26379225
• Crotti S, Enzo MV, Bedin C, Pucciarelli S, Maretto I, Del Bianco P, Traldi P, Tasciotti E, Ferrari M, Rizzolio F, Toffoli G, Giordano A, Nitti D, Agostini M. Clinical predictive circulating peptides in rectal cancer patients treated with neoadjuvant chemoradiotherapy. J Cell Physiol. 2015 Aug;230(8):1822-8. PMID:25522009
• Cecchin E, Perrone G, Nobili S, Polesel J, De Mattia E, Zanusso C, Petreni P, Lonardi S, Pella N, D’Andrea M, Errante D, Rizzolio F, Mazzei T, Landini I, Mini E, Toffoli G. MTHFR-1298 A>C (rs1801131) is a predictor of survival in two cohorts of stage II/III colorectal cancer patients treated with adjuvant fluoropyrimidine chemotherapy with or without oxaliplatin. Pharmacogenomics J. 2015 Jun;15(3):219-25. PMID:25331073
• Ilaria Paterni , Simone Bertini , Carlotta Granchi , Tiziano Tuccinardi , Marco Macchia , Adriano Martinelli , Isabella Caligiuri , Giuseppe Toffoli , Flavio Rizzolio , Kathryn E Carlson , Benita S Katzenellenbogen , John A Katzenellenbogen , and Filippo Minutolo. Highly selective salicylketoxime-based estrogen receptor beta agonists display antiproliferative activities in a glioma model. J. Med. Chem., Just Accepted Manuscript 2015 DOI: 10.1021/jm501829f

2014

• Tuccinardi T, Granchi C, Rizzolio F, Caligiuri I, Battistello V, Toffoli G, Minutolo F, Macchia M, Martinelli A. Identification and characterization of a new reversible MAGL inhibitor. Bioorg Med Chem. 2014 Jul 1;22(13):3285-91. doi: 10.1016/j.bmc.2014.04.057
• Corona G, Polesel J, Fratino L, Miolo G, Rizzolio F, Crivellari D, Addobbati R, Cervo S, Toffoli G. Metabolomics biomarkers of frailty in elderly breast cancer patients. J Cell Physiol. 2014 Jul;229(7):898-902. doi: 10.1002/jcp.24520. PMID:24659054

2013

• Kumar Vinit, Toffoli Giuseppe, Rizzolio Flavio. Fluorescent Carbon Nanoparticles in Medicine for Cancer Therapy. ACS MEDICINAL CHEMISTRY LETTERS Volume: 4 Issue: 11 Pages: 1012-1013 Published: NOV 2013
• Poli G, Tuccinardi T, Rizzolio F, Caligiuri I, Botta L, Granchi C, Ortore G, Minutolo F, Schenone S, Martinelli A. Identification of new Fyn kinase inhibitors using a FLAP-based approach. J Chem Inf Model. 2013 Oct 28;53(10):2538-47. doi: 10.1021/ci4002553. Epub 2013 Sep 16. PMID:24001328
• Ciarcia R, Damiano S, Montagnaro S, Pagnini U, Ruocco A, Caparrotti G, d’Angelo D, Boffo S, Morales F, Rizzolio F, Florio S, Giordano A. Combined effects of PI3K and SRC kinase inhibitors with imatinib on intracellular calcium levels, autophagy, and apoptosis in CML-PBL cells. Cell Cycle. 2013 Sep 1;12(17):2839-48. doi: 10.4161/cc.25920. Epub 2013 Aug 8. PMID: 23966159
• Isabella Caligiuri, Giuseppe Toffoli, Antonio Giordano and Flavio Rizzolio. pRb controls Estrogen Receptor alpha protein stability and activity. Oncotarget. 2013, June 3.
• Lucchetti C, Caligiuri I, Toffoli G, Giordano A, Rizzolio F. The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor α in breast cancer. PLoS One. 2013;8(2):e55355. doi: 10.1371/journal.pone.0055355. Epub 2013 Feb 4.
• Alessio N, Bohn W, Rauchberger V, Rizzolio F, Cipollaro M, Rosemann M, Irmler M, Beckers J, Giordano A, Galderisi U. Silencing of RB1 but not of RB2/P130 induces cellular senescence and impairs the differentiation potential of human mesenchymal stem cells. Cell Mol Life Sci. 2013 May;70(9):1637-51. doi: 10.1007/s00018-012-1224-x. Epub 2013 Jan 31.

2012

• La Montagna R, Caligiuri I, Giordano A, Rizzolio F. Pin1 and nuclear receptors: A new language? J Cell Physiol. 2012 Dec 31. doi: 10.1002/jcp.24316. [Epub ahead of print]
• Toffoli G, Castronovo M, Rizzolio F. Nanotechnology for Circulating Tumor Biomarker Analysis. J Biomark Drug Dev. 2012 Nov 06.
• Marchesi I, Fiorentino FP, Rizzolio F, Giordano A, Bagella L. The ablation of EZH2 uncovers its crucial role in rhabdomyosarcoma formation. Cell Cycle. 2012 Oct 15;11(20):3828-36. doi: 10.4161/cc.22025. Epub 2012 Sep 14.
• Mangani D, Roberti A, Rizzolio F, Giordano A. Emerging molecular networks in Burkitt’s lymphoma. J Cell Biochem. 2012 Aug 17. doi: 10.1002/jcb.24358. [Epub ahead of print]
• La Montagna R, Caligiuri I, Maranta P, Lucchetti C, Esposito L, Paggi MG, Toffoli G, Rizzolio F, Giordano A. Androgen receptor serine 81 mediates Pin1 interaction and activity. Cell Cycle. 2012 Sep 15;11(18).
• Rizzolio F, Caligiuri I, Lucchetti C, Fratamico R, Tomei V, Gallo G, Agelan A, Ferrari G, Toffoli G, Klein-Szanto AJ, Giordano A. Dissecting Pin1 and phospho-pRb regulation. J Cell Physiol. 2012 May 2. doi: 10.1002/jcp.24107
• Manera C, Saccomanni G, Malfitano AM, Bertini S, Castelli F, Laezza C, Ligresti A, Lucchesi V, Tuccinardi T, Rizzolio F, Bifulco M, Di Marzo V, Giordano A, Macchia M, Martinelli A. Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: An investigation of the 1,8-naphthyridin-2(1H)-one scaffold. Eur J Med Chem. 2012 Jun;52:284-94. Epub 2012 Mar 24

2011

• Rizzolio F, Lucchetti C, Caligiuri I, Marchesi I, Caputo M, Klein-Szanto AJ, Bagella L, Castronovo M, Giordano A. Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1. Cell Death Differ. 2012 Feb 10. doi: 10.1038/cdd.2011.202
• Caligiuri I, Rizzolio F, Boffo S, Giordano A, Toffoli G. Critical choices for modeling breast cancer in transgenic mouse models. J Cell Physiol. 2011 Dec 14. doi: 10.1002/jcp.24031.
• Lucchetti C, Rizzolio F, Castronovo M, Toffoli G. Research highlights. PI3K/AKT/mTOR inhibitors would require PI3KCA-mutation analysis. Pharmacogenomics. 2011 Oct;12(10):1382.
• Lucchetti C, Rizzolio F, Castronovo M, Toffoli G. Research highlights. Overcoming BRAF resistance to PLX4032 by AKT inhibition in PTEN-deficient melanoma cells. Pharmacogenomics. 2011 Oct;12(10):1381.
• Lucchetti C, Rizzolio F, Castronovo M, Toffoli G. Research highlights. Protein kinase D3 is the genetic sensitizer of RAF inhibitor RAF265 in melanoma cells. Pharmacogenomics. 2011 Oct;12(10):1380.
• Corona G, Rizzolio F, Giordano A, Toffoli G. Phamaco-metabolomics: an emerging “omics” tool for the personalization of anticancer treatments and identification of new valuable therapeutic targets. J Cell Physiol. 2011 Nov 21. doi: 10.1002/jcp.24003.
• Lucchetti C, Rizzolio F, Castronovo M, Toffoli G. Pharmacogenomics. Research highlights. MCL1 and FBW7 as new predictive candidate biomarkers of anti-tubulin agents. 2011 Oct;12(10):1379-80.
• Paolo Poggio, Juan B. Grau, Benjamin C. Field, Rachana Sainger, William F. Seefried, Flavio Rizzolio, and Giovanni Ferrari. Osteopontin controls endothelial cell migration in vitro and in excised human valvular tissue from patients with Calcific Aortic Stenosis and controls. J Cell Physiol. 2011 Aug;226(8):2139-49
• Roberti A., Rizzolio F., Lucchetti C., de Leval L. and Giordano A. Ubiquitin-mediated protein degradation and methylation-induced gene silencing cooperate in the inactivation of the INK4/ARF locus in Burkitt`s lymphoma cell lines. Cell Cycle. 2011 Jan 1;10(1):127-34.

2010

• Maioli M., Santaniello S., Montella A., Bandiera P., Cantoni S., Cavallini C., Bianchi F., Lionetti V., Rizzolio F., Marchesi I., Bagella L., Ventura C.. Hyaluronan esters drive Smad gene expression and signaling enhancing cardiogenesis in mouse embryonic and human mesenchymal stem cells. PLoS One. 2010 Nov 30;5(11):e15151.
• Federico M, Symonds CE, Bagella L, Rizzolio F, Fanale D, Russo A, Giordano A. R-Roscovitine (Seliciclib) prevents DNA damage-induced cyclin A1 upregulation and hinders non-homologous end-joining (NHEJ) DNA repair. Mol Cancer. 2010 Aug 4;9:208.
• Rizzolio F, La Montagna R, Tuccinardi T, Russo G, Caputi M, Giordano A. Adenosine Receptor Ligands in Clinical Trials. Curr Top Med Chem. 2010;10(10):1036-45.
• Rizzolio F. and Giordano A.. Cell Cycle Control: A Brief Historical Overview. SignalChem Connected E-news. Volume 7, Issue 1 2010 Jan 27
• Rizzolio F, Tuccinardi T, Caligiuri I, Lucchetti C, Giordano A. CDK Inhibitors: From the Bench to Clinical Trials. Curr Drug Targets. 2010 Mar;11(3):279-90.
• Rizzolio F, Esposito L, Muresu D, Fratamico R, Jaraha R, Caprioli GV, Giordano A. RB gene family: Genome-wide ChIP approaches could open undiscovered roads. J Cell Biochem. 2010 Apr 1;109(5):839-43.

2009

• Rizzolio F., Pramparo T,, Sala C., Zuffardi O., DeSantis L., Rabellotti E., Calzi F., Fusi F., Bellazzi R., and Toniolo D.. Epigenetic analysis of the Critical Region I for Premature Ovarian Failure (POF): demonstration of a highly heterochromatic domain on the long arm of the mammalian X chromosome. J.Med Genet. 2009 Sep;46(9):585-92

2008

• Rizzolio F, Bione S, Sala C, Tribioli C, Ciccone R, Zuffardi O, et al. Highly conserved non-coding sequences and the 18q critical region for short stature: A common mechanism of disease? PLoS ONE. 2008 Jan 23;3(1):e1460.

2007

• Toniolo D. and Rizzolio F.. “X chromosome and ovarian failure” Seminars in Reproductive Medicine, in press 2007
• Rizzolio F, Sala C, Alboresi S, Bione S, Gilli S, Goegan M, et al. Epigenetic control of the critical region for premature ovarian failure on autosomal genes translocated to the X chromosome: A hypothesis. Hum Genet. 2007 May;121(3-4):441-50.
• Rizzolio F., Bione S., Villa A., Berti E., Cassetti A., Bulfone A., Tribioli C., Toniolo D.. Spatial and temporal expression of POF1B, a gene expressed in epithelia. Gene exp. Patterns 2007 Feb;7(4):529-34

2006

• Rizzolio F., Bione S., Sala C., Goegan M., Gentile M., Gregato G., Rossi E., Pramparo T., Zuffardi O. and Toniolo D.. X chromosome rearrangements and premature ovarian failure (POF): mapping of 25 new cases and review of the literature. Hum Reprod. 2006 Jun;21(6):1477-83.

2004

• Bione S., Rizzolio F., Sala C., Ricotti R., Goegan M., Manzini MC., Battaglia R., Marozzi A., Vegetti W., Dalprà L., Crosignani PG., Ginelli E., Nappi R., Bernabini S., Bruni V., Torricelli F., Zuffardi O. and Toniolo D. Mutation analysis of two candidate genes for Premature Ovarian Failure (POF), DACH2 and POF1B. Human Reproduction 19:2759-66, 2004.
• Rossetti F., Rizzolio F., Pramparo T., Sala C., Bione S., Bernardi F., Goegan M., Zuffardi O. and Toniolo D. A susceptibily gene for Premature Ovarian Failure (POF) maps to proximal Xq28. Eur J Hum Genet.12:829-834, 2004.

2000

• Meloni I., Bruttini M., Longo I, Mari F., Rizzolio F., D’Adamo P., Denvriendt K., Fryns JP., Toniolo D., Renieri A. A Mutation in the Rett Syndrome Gene, MECP2, Causes X-Linked Mental Retardation and Progressive Spasticity in Males. Am J Hum Genet.67:982-985, 2000.

• Viviana Canale, PhD student