NANO-BIOMATERIALS

Academic year
2022/2023 Syllabus of previous years
Official course title
NANO-BIOMATERIALS
Course code
CM1314 (AF:355499 AR:186384)
Modality
On campus classes
ECTS credits
6
Degree level
Master's Degree Programme (DM270)
Educational sector code
BIO/10
Period
1st Semester
Course year
2
Moodle
Go to Moodle page
This course will provide basic and intermediate level knowledge on the fabrication and characterization of nano-biomaterials, focusing on DNA-based nanomaterials.
At the end of the course, students are expected to know the design principles of simple nano-objects made of DNA. Students will know the main techniques for the characterization of such nanostructures and the computer-based tools for structural analysis of DNA nanoastructures.
An intermediate-to-advanced understanding of the biochemistry of nucleic acids is required.
1- BIOPOLYMERS FOR SELF-ASSEMBLY:

PROTEINS
DNA (ssDNA, dsDNA, TRIPLEX, QUADRUPLEX,HAIRPIN, TILING, Y-SHAPED DNA, TWEEZERS, CATENANES)
RNA


2- COMPOSITE NANOBIOMATERIALS:

SURFACE MODIFICATION OF NANOPARTICLES
CHEMICAL FUNCTIONALIZATION OF CARBON-BASED NANOMATERIALS
SURFACE ADSORPTION OF MOLECULES
NANOPORES LOADING


3- PROPERTIES AND APPLICATIONS OF NANOBIOMATERIALS:

MULTIFUNCTIONALITY
MAGNETIC DRIVEABILITY
PHOTO-THERMAL CONVERSION
LSPR
CHIROPLASMONICS
TARGETED DELIVERY
THERANOSTICS


4- SMART NANOBIOMATERIALS:

RECONFIGURABLE MATTER
PROGRAMMABLE MATTER
STIMULI-RESPONSIVE MATTER


5- CASE STUDY:

DNA ORIGAMI
LEGO-LIKE DNA
DNA BOX


6- COMPUTER-ASSISTED MODELING

DNA AND RNA SECONDARY STRUCTURES (NUPACK)
DNA ORIGAMI SEQUENCE DESIGN (CadNano)
3D REPRESENTATION OF ORIGAMI STRUCTURES (CanDo)
Lecture notes and scientific publications provided during lectures.
Oral exam as reported in the exam calendar. Students are allowed to present an experimental publication of their choice with a slide-assisted talk (15-20 minutes), after which some questions pertaining the talk will be asked.
Contents will be presented via lectures. Students will attend a bioinformatics laboratory where they will model a DNA structure and produce the strands necessary to fabricate the nanostructure.
English
oral
Definitive programme.
Last update of the programme: 01/08/2022