LABORATORY OF ORGANIC CHEMISTRY 2 - MOD.2

This course is one of the core educational activities of the Bachelor's Degree in Chemistry and Sustainable Technologies, designed to provide students with the skills needed to address chemical problems from a practical and experimental perspective, through the appropriate use of laboratory techniques and instrumentation.
Specifically, this module aims to develop practical skills in experimental organic chemistry, enabling students to design and carry out organic reactions and to critically interpret the results. The Organic Chemistry Laboratory II - Module 2 course is therefore intended both to consolidate and expand the fundamental knowledge acquired in Organic Chemistry I and Organic Chemistry I Laboratory - Module 2, and to introduce students to the main laboratory techniques and data analysis methods used in organic chemistry.

1. Knowledge and Understanding
- Understand the main equipment, techniques, and operational methodologies used in an organic synthesis laboratory.
- Comprehend the fundamental principles of organic synthesis experiments, including product isolation, purification, and result analysis.

2. Applying Knowledge and Understanding
- Identify and correctly operate various laboratory equipment and instrumentation.
- Read, interpret, and implement experimental procedures in a laboratory setting.
- Perform a coherent sequence of laboratory operations safely and reproducibly.
- Interpret experimental data and draft a technical report documenting the work carried out.

3. Autonomy of Judgment
Depending on the level of subject mastery:
- Evaluate the correct execution and effectiveness of a synthesis experiment.
- Recognize and handle organic compounds appropriately, taking into account their potential hazards to human health and the environment.

4. Communication Skills
- Use appropriate scientific and technical terminology in the field of organic chemistry.
- Clearly and concisely present experimental methodologies and results in a scientific report.
- Interact constructively with instructors, tutors and peers by asking relevant questions using proper scientific language.

5. Learning Skills
- Keep an accurate and systematic laboratory notebook recording all activities performed.
- Critically analyze and interpret experimental results in order to draw well-supported conclusions.

Students are expected to have achieved the learning objectives of the Organic Chemistry I and Laboratory course. A solid knowledge of the main operational techniques used in a chemistry laboratory is required, including: distillation, chromatography, separation, extraction, heating, stirring, reflux, weighing, volumetric measurements, and molarity calculations. A good familiarity with the nomenclature of laboratory equipment and techniques is also recommended.
It is strongly advised that students have passed the Organic Chemistry I and Laboratory exam before enrolling in this course.

The preparatory lectures for the Organic Chemistry II Laboratory are designed to provide students with the theoretical foundation necessary to approach the experimental activities with awareness and autonomy. Specifically, the lectures will cover:
• A description of the main techniques and equipment used in the teaching laboratory;
• A detailed presentation of the individual laboratory experiments included in the course;
• Methodologies related to chemical reactions, product isolation, and purification techniques;
• The interpretation of experimental data, including introductory concepts of NMR spectroscopy and gas chromatography coupled with mass spectrometry (GC-MS).

During the laboratory sessions, students will carry out five practical experiments aimed at applying techniques and methodologies typical of experimental organic chemistry. The following reactions will be covered:
• Grignard Reaction
• Friedel–Crafts Acylation
• Wadsworth–Emmons Reaction
• Multistep Reaction: Aldol Condensation / Michael Addition / Cyclization
• Knoevenagel Reaction
Each experiment will be accompanied by data analysis and critical discussion of the procedures employed.

Jonathan Clayden, Nick Greeves, Stuart Warren "Organic Chemistry", 2nd Edition, Oxford University Press, 2012, ISBN: 978-01-992-7029-3
Marco D'Ischia "La Chimica Organica in Laboratorio", Piccin, 2003, ISBN: 978-88-299-1621-4
Antonio Randazzo "Guida Pratica alla Interpretazione di Spettri NMR", Loghia, 2018, ISBN: 978-88-951-2242-7
Robert M. Silverstein, Francis X. Webster, David J. Kiemle, David L. Bryce "Spectrometric Identification of Organic Compounds", 8th Edition, Wiley, 2014, ISBN: 978-81-265-5659-5

Additional titles are available through the University Library System: http://uve-iua-primo.hosted.exlibrisgroup.com/primo-explore/search?query=any,contains,practical%20organic%20chemistry&vid=unive_new_ui&facet=rtype,include,books&lang=it_IT&offset=0

Student learning in the Organic Chemistry II and Laboratory – Modules 1 and 2 course is assessed through three main components: a written exam, an oral exam, and the evaluation of laboratory reports.
Access to the oral exam is conditional upon passing the written exam and the submission and positive evaluation of the written laboratory reports related to the experimental part of the course. The oral exam may be taken, at the student’s discretion and in accordance with the University’s exam schedule, starting from one week after the written exam.
The written exam, which lasts approximately 2 hours, consists of a series of exercises covering the entire course content (see Contents section). It is designed to assess the student’s ability to solve problems related to organic synthesis and retrosynthesis, and to propose logically sound reaction mechanisms. The use of textbooks, notes, or electronic devices is not permitted during the written exam.
The oral exam consists of a series of questions on the course topics. Students are expected to demonstrate a solid understanding of the subject matter, as well as the ability to communicate clearly and accurately using appropriate scientific terminology and chemical symbolism. The oral exam typically lasts between 15 and 30 minutes, depending on the clarity and coherence of the responses.
The final grade is primarily based on the written exam result (approximately 80–85% of the total score), while the oral exam and the laboratory reports serve to adjust the final mark, either positively or negatively.

written and oral

The final grade reflects the overall level of knowledge of the course content, the ability to connect and integrate different topics, the quality of laboratory work, and the accuracy of written reports. The evaluation criteria are as follows:
- Grade 18–22: Basic knowledge of the course content; sufficient ability to connect the main topics discussed; laboratory activities and reports are adequate, though may contain inaccuracies or be incomplete.
- Grade 23–26: Fairly good understanding of the content; good ability to integrate and relate different topics; accurate laboratory work, with detailed and correct reports.
- Grade 27–28: Thorough and well-structured knowledge of the subject; very good ability to synthesize and interconnect concepts; excellent laboratory work, with complete, clear, and error-free reports.
- Grade 29–30: Excellent mastery of the course content; autonomous and consistent reasoning, including on complex interrelated topics; impeccable laboratory activities and reports.
- Grade 30 with honors (lode): As for the 29–30 range, with the additional ability to solve advanced questions or unfamiliar problems, including reactions not discussed in class, showing critical thinking and independent deepening of the subject matter.

Module 2 of the Organic Chemistry II anf Laboratory course combines theoretical instruction with hands-on laboratory experience, structured as follows:
• 12 hours (6 lectures) of introductory lecture, aimed at providing the theoretical background necessary to approach the laboratory activities in a safe and informed manner;
• 48 hours (6 sessions) of laboratory work, dedicated to carrying out organic synthesis experiments, analyzing experimental data, and writing technical reports.
The course is designed to promote active learning, the acquisition of practical skills, and the development of critical thinking in interpreting experimental results.

Accessibility, Disability and Inclusion

Accommodations and Support Services for students with disabilities or with specific learning disabilities:
Ca 'Foscari applies Italian law (Law 17/1999; Law 170/2010) for support and accommodation services available to students with disabilities or with specific learning disabilities. In case of motor, visual, hearing or other disabilities (Law 17/1999) or a specific learning disorder (Law 170/2010) and you need support (classroom assistance, technological aids for carrying out exams or individualized exams, material in accessible format, recovery of notes, specialized tutoring to support the study, interpreters or other), contact the Disability and SLD office. disabilita@unive.it.

This subject deals with topics related to the macro-area "Circular economy, innovation, work" and contributes to the achievement of one or more goals of U. N. Agenda for Sustainable Development