Applications of Bio and nanomaterials for human health

Research Group

Flavio Rizzolio,  Associate Professor
Matteo Mauceri, PhD Candidate
Hirano Sota, PhD Candidate
Muhammad Adeel, PhD Candidate (Supervisor: Prof. Vincenzo Canzonieri)

Collaborations

Prof. Antonio Giordano, Temple University-Philadelphia, US
Prof. Vincenzo Canzonieri, National Cancer Institute-IRCCS-Aviano and University of Trieste, Italy
Prof. Tiziano Tuccinardi, University of Pisa, Italy
Dott. Marco Agostini, Istituto di Ricerca Pediatrica Città della Speranza -Padova, Italy

Research topics

Development of Bio and nanomaterials in oncology

In collaboration with the National Cancer Center of Aviano, the University of Pisa (Prof. Tiziano Tuccinardi and Carlotta Granchi) and Temple University (Prof. Antonio Giordano) the research group is developing new nanopharmaceuticals based on biocompatible materials (e.g. DNA, liposomes, exosomes).

Selected Publications

  • Liposomal delivery of a Pin1 inhibitor complexed with cyclodextrins as new therapy for high-grade serous ovarian cancer. Russo Spena C, De Stefano L, Palazzolo S, Salis B, Granchi C, Minutolo F, Tuccinardi T, Fratamico R, Crotti S, D'Aronco S, Agostini M, Corona G, Caligiuri I, Canzonieri V, Rizzolio F. J Control Release. 2018 May 8;281:1-10. doi: 10.1016/j.jconrel.2018.04.055. PMID: 29746956
  • Bottom-up synthesis of carbon nanoparticles with higher doxorubicin efficacy. Bayda S, Hadla M, Palazzolo S, Kumar V, Caligiuri I, Ambrosi E, Pontoglio E, Agostini M, Tuccinardi T, Benedetti A, Riello P, Canzonieri V, Corona G, Toffoli G, Rizzolio F. J Control Release. 2017 Feb 28;248:144-152. doi: 10.1016/j.jconrel.2017.01.022. Epub 2017 Jan 14. PMID: 28093297

Development of innovative Biobanks in Oncology

In collaboration with the National Cancer Center of Aviano (Dr. Vincenzo Canzonieri) and the Pediatric Research Institute Città della Speranza (Dr. Marco Agostini), new biomolecular and cellular approaches are being developed for the creation of biobanks derived from healthy tissues and tumors from cancer patients.

Selected Publications

  • Decellularized colorectal cancer matrix as bioactive microenvironment for in vitro 3D cancer research. Piccoli M, D'Angelo E, Crotti S, Sensi F, Urbani L, Maghin E, Burns A, De Coppi P, Fassan M, Rugge M, Rizzolio F, Giordano A, Pilati P, Mammano E, Pucciarelli S, Agostini M. J Cell Physiol. 2018 Aug;233(8):5937-5948. doi: 10.1002/jcp.26403. Epub 2018 Feb 27. PMID: 29244195
  • Cost-effective organization of an institutional human cancer biobank in a clinical setting: CRO-Biobank experience toward harmonization. Cervo S, De Paoli P, Perin T, Canzonieri V, Steffan A. Int J Biol Markers. 2015 May 26;30(2):e243-51. doi: 10.5301/jbm.5000138. PMID: 25744364

Emerging environmental contaminants

Contaminants are a recurring problem in the environment and food. We are developing new molecular tests for the protection of human health.

Last update: 07/07/2020