Alessandro ANGELINI
- Position
- Associate Professor
- Telephone
- 041 234 8944 / 041 234 8590 / 041 234 8600 / 041 234 8604
-
alessandro.angelini@unive.it
- Academic discipline
- Biochemistry [BIOS-07/A]
- Website
-
https://www.unive.it/web/en/19197/people/alessandro.angelini(personal record)
- Office
-
Department of Molecular Sciences and Nanosystems
Website: https://www.unive.it/dep.dsmn
Where: Campus scientifico via Torino
Room: room 613 (ALFA building, 6th floor) / research lab 1 (BETA building, 3rd floor)
- Office
-
European Center for Living Technology (ECLT)
Where: Ca' Bottacin
- Safety Role
-
Preposto di Laboratorio
Responsabile dell’Attività di Didattica e Ricerca in Laboratorio (RDRL)
Teaching activity current year
Teaching activity previous years
SCIENCE AND TECHNOLOGY OF BIO AND NANOMATERIALS [CM14]
Laurea magistrale (DM270)
CHIMICA E TECNOLOGIE SOSTENIBILI [CM7]
Laurea magistrale (DM270)
CHIMICA E TECNOLOGIE SOSTENIBILI [CT7]
Laurea
INGEGNERIA FISICA [CT8]
Laurea
SCIENZA E TECNOLOGIA DEI BIO E NANOMATERIALI [R356]
Corso di Dottorato (D.M.226/2021)
SCIENCE AND TECHNOLOGY OF BIO AND NANOMATERIALS [CM14]
Laurea magistrale (DM270)
CHIMICA E TECNOLOGIE SOSTENIBILI [CM7]
Laurea magistrale (DM270)
CHIMICA E TECNOLOGIE SOSTENIBILI [CT7]
Laurea
INGEGNERIA FISICA [CT8]
Laurea
SCIENZA E TECNOLOGIA DEI BIO E NANOMATERIALI [R256]
Corso di Dottorato (D.M.45)
Activities and research skills
- Academic discipline
- Biochimica [BIOS-07/A]
- Settore Scientifico Disciplinare (SSD) affine
- Chimica farmaceutica [CHEM-07/A]
- Geographic areas in which the research experience mainly applies
- Internazionale: Europa, America Settentrionale
- Known languages
-
Italiano
(scritto: madrelingua parlato: madrelingua)
Inglese (scritto: avanzato parlato: avanzato)
- Participation in editorial boards of scientific journals/book series
-
2022 – present: Associate editor for Molecular Recognition – Frontiers Molecular Biosciences
2024 – present: Associate editor for Molecular Diagnostics and Therapeutics – Frontiers Molecular Biosciences
- Participation as referees of national and international research projects
-
1. Referee for research grant application proposals to the Dutch Research Council (NOW – Netherlands)
2. Referee for research grant application proposals to the Auckland Medical Research Foundation (AMRF – New Zealand)
3. Referee for research grant application proposals to the EUTOPIA Alliance (European Union)
4. Referee for research grant application proposals to the Swiss National Science Foundation (SNSF – Switzerland)
5. Referee for research grant application proposals to the French National Research Agency (ANR – France)
6. Referee for research grant application proposals to the Experientia Foundation (Czech Republic)
7. Referee for research grant application proposals to the Israel Science Foundation (ISF – Israel)
- Main departmental research areas and fields
-
Area:
Biomedicina Linea:
Diagnosi
Area: Biomedicina Linea: Terapia
Area: Chimica Fisica e Materiali Linea: Sintesi Organica
Area: Informatica Linea: ARTIFICIAL INTELLIGENCE
Area: Informatica Linea: BIOINFORMATICS
- Evoluzione molecolare di peptidi e proteine
-
- Description:
- Molecular evolution of peptides and proteins
- Keywords:
- Applied biology, Molecular evolution, Structural biology
- ATECO code:
- [72.11] - ricerca e sviluppo sperimentale nel campo delle biotecnologie
- Sviluppo di nuove tecnologie per evoluzione diretta di biomolecole codificate geneticamente
-
- Description:
- Development of novel technologies for the directed evolution of genetically encoded biomolecules
- Keywords:
- Biochemical technology, Genetic selection, Genetically modified organisms
- ATECO code:
- [72.11] - ricerca e sviluppo sperimentale nel campo delle biotecnologie
- Bioingegneria di peptidi e proteine terapeutiche
-
- Description:
- Bioengineering of therapeutic peptides and proteins
- Keywords:
- Molecular design, de novo design, Monoclonal antibodies, Molecular markers and recognition
- ATECO code:
- [72.11] - ricerca e sviluppo sperimentale nel campo delle biotecnologie
- Sviluppo di peptidi macrociclici per la medicina di precisione
-
- Description:
- Development of macrocyclic peptides for precision medicine
- Keywords:
- Combinatorial chemistry, Molecular chemistry, Macromolecular chemistry
- Computational drug discovery
-
- Other members of the research group:
-
Leone BACCIU
Achille GIACOMETTI
Matteo GRAZIOSO
Silvia MULTARI
Marco Salvatore NOBILE
- Development and characterisation of macrocyclic peptides
-
- SSD:
- BIO/10
- Development of novel directed evolution methodologies and recombinant surface display technologies
-
- SSD:
- BIO/10
- Other members of the research group:
-
Sara LINCIANO
- Ottimizzazione sintesi peptidi su fase solida e relative modifiche strutturali
-
- SSD:
- CHIM/06
- Other members of the research group:
-
Alessandro SCARSO
- Selection and engineering of antibodies and nanobodies
-
- SSD:
- BIO/10
- Other members of the research group:
-
Zhanna ROMANYUK
- Selection and engineering of genetically encoded peptides and proteins
-
- SSD:
- BIO/10
- Other members of the research group:
-
Ylenia MAZZOCATO
- Sintesi di derivati peptidici coniugati per medicinal chemistry di precisione
-
- SSD:
- CHIM/06
- Other members of the research group:
-
Alessandro SCARSO
- Sintesi selettive e sostenibili di peptidi mediante minimizzazione scarti
-
- SSD:
- CHIM/06
- Other members of the research group:
-
Alessandro SCARSO
- Targeted drug delivery and imaging
-
- SSD:
- CHEM-07/A
- Other members of the research group:
-
Francesca BORDIGNON
Sara LINCIANO
- A novel integrated cyclic peptide-based platform for precision delivery of nucleic acid-based therapeutics (ALLIANCE)
-
- Funding body:
- National Center for Gene Therapy and Drugs based on RNA - Piano Nazionale di Ripresa e Resilienza (PNRR) - Ministero dell'università e della ricerca e Unione Europea (NextGenerationEU)
- Type:
- Altri programmi ministeriali
- Role in the project:
- LD
- Starting date:
- Year: 2024 Length in months: 12
- Class IIa HDACs as therapeutic targets in human diseases: new roles and new selective inhibitors
-
- Funding body:
- Ministry of Education, University and Research (MIUR)
- Type:
- PRIN
- Role in the project:
- PT
- Starting date:
- Year: 2019 Length in months: 36
- Il criceto dorato (Mesocricetus auratus) come modello animale per l’utilizzo di anticorpi monoclonali a scopo terapeutico per le malattie infettive a carattere zoonosico
-
- Funding body:
- The Ministry of Health
- Type:
- Altri programmi ministeriali
- Role in the project:
- PT
- Starting date:
- Year: 2020 Length in months: 24
- Macrocyclic peptides targeting unexplored class IIa HDAC binding sites: towards the development of novel cancer therapy
-
- Funding body:
- Fondazione AIRC per la Ricerca sul Cancro e Commissione Europea (Horizon 2020)
- Type:
- Altri finanziamenti per progetti di ricerca
- Role in the project:
- LD
- Starting date:
- Year: 2020 Length in months: 36
- Novel molecular target for diagnosis and therapy in early esophageal cancer
-
- Funding body:
- The Ministry of Health
- Type:
- Altri programmi ministeriali
- Role in the project:
- PT
- Starting date:
- Year: 2021 Length in months: 36
- Reducing SARS-CoV-2 spread in the human body via the aerosolized delivery of cell-shielding PEGylated bicyclic peptides (RELIEVED)
-
- Funding body:
- Ministry of Education, University and Research (MIUR)
- Type:
- FIRB/FIR/SIR
- Role in the project:
- LD
- Starting date:
- Year: 2021 Length in months: 6
- Sviluppo di un bioprocesso innovativo e biocompatibile per la produzione sostenibile di nanosistemi di diagnostica molecolare a base peptidica in Veneto
-
- Funding body:
- European Social Fund Plus (ESF+) – Veneto Regional Programme 2021/2027
- Type:
- Altri finanziamenti per progetti di ricerca
- Role in the project:
- LD
- Starting date:
- Year: 2023 Length in months: 12
- Other members of the research group:
-
Giulia FIORANI
Achille GIACOMETTI
Federico POLO
Alessandro SCARSO
- Targeting class IIa HDACs to reset super-enhancers activity in cancer cells: towards selective epigenetic therapies in the 3D reality
-
- Funding body:
- Ministero dell’Univerista’ e della Ricerca (MUR)
- Type:
- PRIN
- Role in the project:
- PT
- Starting date:
- Year: 2024 Length in months: 24
Publication highlights
Bettin, Giacomo; Salvadoretti, Matilde; Rossi, Guglielmo; Fabris, Fabrizio; Bonetto, Alessandro; Brancolini, Claudio; Scarso, Alessandro; Angelini, Alessandro An affordable and low-waste protocol for rapid and robust solid-phase peptide synthesis at elevated temperatures in BIOORGANIC CHEMISTRY, vol. 181 (ISSN 0045-2068)
DOI 2026,
Journal Article - ARCA card: 10278/5122870
Cortolezzis, Ylenia; Tolotto, Vanessa; Triboli, Luca; Picco, Raffaella; Soler, Miguel A; Fortuna, Sara; Bettin, Giacomo; D'Este, Francesca; Carlassara, Enrico; Magris, Gabriele; Miller, Kyle; Angelini, Alessandro; Xodo, Luigi E; Di Giorgio, Eros RPA hyperphosphorylation hinders the resolution of R-loops and G-quadruplex-associated R-loops during RAS-driven senescence in NUCLEIC ACIDS RESEARCH, vol. 54 (ISSN 0305-1048)
DOI 2026,
Journal Article - ARCA card: 10278/5116767
Romanyuk, Zhanna; Bettin, Giacomo; Brear, Paul; Linciano, Sara; Mazzocato, Ylenia; Bonadies, Simone; Zanotto, Ilaria; Mazzucco, Camilla; Monferone, Alan; Soler, Miguel A.; Pasut, Gianfranco; Martin, Sara De; Scarso, Alessandro; Heinis, Christian; Rothenberger, Sylvia; Hyvönen, Marko; Angelini, Alessandro Yeast Display Technology Enables Rapid Discovery of Low-Nanomolar Macrocyclic Peptide Inhibitors of Human Angiotensin-Converting Enzyme 2 in JOURNAL OF MEDICINAL CHEMISTRY, vol. 69, pp. 7689-7708 (ISSN 0022-2623)
DOI 2026,
Journal Article - ARCA card: 10278/5115268
Bordignon, Francesca; Scarso, Alessandro; Angelini, Alessandro Challenges and Achievements of Peptide Synthesis in Aqueous and Micellar Media in CHEMBIOCHEM, vol. e202500099 (ISSN 1439-4227)
DOI 2025,
Journal Article - ARCA card: 10278/5095768
Malavasi, Eleonora; Picco, Raffaella; Mallavarapu, Showmeya; Minisini, Martina; D'Este, Francesca; Bertozzo, Alessio; Giuliani, Lidia; Astolfi, Roberta; Chinellato, Monica; Bettin, Giacomo; Bortoluzzi, Marco; Ragno, Rino; Angelini, Alessandro; Brancolini, Claudio Identification of a novel minor-groove DNA binder that represses mitochondrial gene expression and induces apoptosis in highly aggressive leiomyosarcoma cells in CELL DEATH DISCOVERY, vol. 11 (ISSN 2058-7716)
DOI 2025,
Journal Article - ARCA card: 10278/5106467