Flavio RIZZOLIO

Position
Full Professor
Telephone
041 234 8910
E-mail
flavio.rizzolio@unive.it
Academic discipline
Molecular Biology [BIOS-08/A]
Website
https://www.unive.it/people/flavio.rizzolio (personal record)
 https://www.unive.it/bio-nanotechnology-lab
Office
Department of Molecular Sciences and Nanosystems
Website: https://www.unive.it/dep.dsmn
Where: Campus scientifico via Torino
Room: office 17 (Gamma building, ground floor) / research lab 5 (Gamma building, ground floor)
Office
European Center for Living Technology (ECLT)
Where: Ca' Bottacin
Office
Interconnected Nord-Est Innovation Ecosystem - Temporary Project Centre
Research Institute
Research Institute for Complexity
Safety Role
Preposto di Laboratorio
Responsabile dell’Attività di Didattica e Ricerca in Laboratorio (RDRL)

Office hours

Teaching activity current year

CHIMICA [CTR70]
Bachelor's Degree Programme

CHIMICA E TECNOLOGIE SOSTENIBILI [CMR7]
Master's Degree Programme (DM270)

CHIMICA E TECNOLOGIE SOSTENIBILI [CT7]
Bachelor's Degree Programme

CHIMICA E TECNOLOGIE SOSTENIBILI [CTR7]
Bachelor's Degree Programme

INGEGNERIA FISICA [CT8]
Bachelor's Degree Programme

INGEGNERIA FISICA [CTR8]
Bachelor's Degree Programme

SCIENCE AND TECHNOLOGY OF BIO AND NANOMATERIALS [CM14]
Master's Degree Programme (DM270)

Teaching activity previous years

SCIENCE AND TECHNOLOGY OF BIO AND NANOMATERIALS [CM14]
Master's Degree Programme (DM270)

CHIMICA E TECNOLOGIE SOSTENIBILI [CM7]
Master's Degree Programme (DM270)

CHIMICA E TECNOLOGIE SOSTENIBILI [CMR7]
Master's Degree Programme (DM270)

CHIMICA E TECNOLOGIE SOSTENIBILI [CT7]
Bachelor's Degree Programme

INGEGNERIA FISICA [CT8]
Bachelor's Degree Programme

CHIMICA E TECNOLOGIE SOSTENIBILI [CTR7]
Bachelor's Degree Programme

INGEGNERIA FISICA [CTR8]
Bachelor's Degree Programme

ENGINEERING PHYSICS AND MATERIALS [R361]
Corso di Dottorato (D.M.226/2021)

SCIENCE AND TECHNOLOGY OF BIO AND NANOMATERIALS [CM14]
Master's Degree Programme (DM270)

CHIMICA E TECNOLOGIE SOSTENIBILI [CM7]
Master's Degree Programme (DM270)

CHIMICA E TECNOLOGIE SOSTENIBILI [CT7]
Bachelor's Degree Programme

INGEGNERIA FISICA [CT8]
Bachelor's Degree Programme

SCIENZA E TECNOLOGIA DEI BIO E NANOMATERIALI [R356]
Corso di Dottorato (D.M.226/2021)

SCIENCE AND TECHNOLOGY OF BIO AND NANOMATERIALS [CM12]
Master's Degree Programme (DM270)

SCIENCE AND TECHNOLOGY OF BIO AND NANOMATERIALS [CM14]
Master's Degree Programme (DM270)

CHIMICA E TECNOLOGIE SOSTENIBILI [CM7]
Master's Degree Programme (DM270)

CHIMICA E TECNOLOGIE SOSTENIBILI [CT7]
Bachelor's Degree Programme

INGEGNERIA FISICA [CT8]
Bachelor's Degree Programme

SCIENZA E TECNOLOGIA DEI BIO E NANOMATERIALI [R256]
Corso di Dottorato (D.M.45)

SCIENCE AND TECHNOLOGY OF BIO AND NANOMATERIALS [CM12]
Master's Degree Programme (DM270)

CHIMICA E TECNOLOGIE SOSTENIBILI [CM7]
Master's Degree Programme (DM270)

CHIMICA E TECNOLOGIE SOSTENIBILI [CT7]
Bachelor's Degree Programme

INGEGNERIA FISICA [CT8]
Bachelor's Degree Programme

SCIENZA E TECNOLOGIA DEI BIO E NANOMATERIALI [R256]
Corso di Dottorato (D.M.45)

SCIENCE AND TECHNOLOGY OF BIO AND NANOMATERIALS [CM12]
Master's Degree Programme (DM270)

CHIMICA E TECNOLOGIE SOSTENIBILI [CM7]
Master's Degree Programme (DM270)

CHIMICA E TECNOLOGIE SOSTENIBILI [CT7]
Bachelor's Degree Programme

SCIENZA E TECNOLOGIA DEI BIO E NANOMATERIALI [R256]
Corso di Dottorato (D.M.45)

Activities and research skills

Academic discipline
Biologia molecolare [BIOS-08/A]
Settore Scientifico Disciplinare (SSD) affine
BIOLOGIA MOLECOLARE [BIO/11]
Geographic areas in which the research experience mainly applies
Internazionale: Europa
Known languages
italiano (scritto: madrelingua parlato: madrelingua)
inglese (scritto: avanzato parlato: avanzato)
Participation in editorial boards of scientific journals/book series
-Editorial Board: BMC Cancer, 2021-
-Editorial Board: Diagnostic Pathology, 2021-
-Editorial Board: Chinese Clinical Oncology, 2020-
-Guest Editor: Cancer Organoids in Basic Science and Translational Medicine, Cancers, 2019
-Guest Editor: Breakthrough in drug discovery and delivery in oncology, Molecules, 2019
-Guest Editor: Biocompatible Materials in Drug Delivery System in Oncology, Pharmaceutics, 2019
-Guest Editor: Recent Advances in Nanomedicine for Cancer Treatment, Journal of Oncology, Hindawi, 2019
-Guest Editor: Peptidyl-prolyl Isomerases in Human Pathologies. Frontiers in Pharmacology, 2018
-Guest Editor: Nanomedicine in cancer. Current Medicinal Chemistry, 2016
-Frontiers in Nanoscience and Nanotechnology, OAT 2016-
-Nanomedicine & Nanoscience Research, Gavin publisher 2016-
Participation as referees of national and international research projects
TRANSCAN projects
National Research Foundation-Republic of South Africa
Swiss National Foundation
Main departmental research areas and fields
Area: Biomedicina Linea: Diagnosi
Area: Biomedicina Linea: Salute e Benessere
Area: Biomedicina Linea: Terapia
Area: Biomedicina
Sviluppo di farmaci in ambito oncologico
Description:
Drug discovery for cancer
Keywords:
Health sciences, Anticancer therapy, Nanosystems
ATECO code:
[72] - ricerca scientifica e sviluppo
Nanomateriali per la veicolazione di farmaci
Description:
Nanotechnology for drug delivery
Keywords:
Technological sciences, Nanosystems
ATECO code:
[72] - ricerca scientifica e sviluppo
Functional analysis of cell cycle genes in cancer
SSD:
BIO/11
Genetic and epigenetic analysis of X linked candidate genes for Premature Ovarian Failure
SSD:
BIO/11
Organ-on-chip
SSD:
BIO/11
Targeted therapy in colorectal and ovarian cancers and development of new drug delivery systems
SSD:
BIO/11
A novel nanopharmaceutical formulation for the treatment of solid tumors
Funding body:
Ministero della Salute
Type:
Altri programmi ministeriali
Role in the project:
LD
Starting date:
Year: 2024 Length in months: 36
Cibo intelligente per un futuro sostenibile
Funding body:
Regione Veneto
Type:
POR FESR (2014-2020)
Role in the project:
PT
Starting date:
Year: 2017 Length in months: 12
Development of a diagnostic kit to isolate circulating exosomes in patients with ovarian cancer
Funding body:
AREA Science Park
Type:
Altri finanziamenti per progetti di ricerca
Role in the project:
PT
Starting date:
Year: 2015 Length in months: 12
ISE-EMH, Ecosistema italo-sloveno per la sanità elettronica e mobile
Funding body:
Europa
Type:
Interreg V Italia - Slovenia
Role in the project:
PT
Sito di progetto:
https://www.ita-slo.eu/it/ise-emh
Starting date:
Year: 2020 Length in months: 36
Inhibition of Pin1 to improve carboplatin and taxol cytotoxicity in high-grade serous ovarian cancer
Funding body:
AIRC
Type:
Altri finanziamenti per progetti di ricerca
Role in the project:
NS
Starting date:
Year: 2015 Length in months: 36
Nanosalus: Nanomateriali terapeutici a delivery ottimizzato per la salute umana
Funding body:
MIMIT
Type:
Altri programmi ministeriali
Role in the project:
LD
Starting date:
Year: 2023 Length in months: 36
New diagnostic and therapeutic tools against multidrug resistant tumors
Funding body:
Europa
Type:
COST
Role in the project:
PT
Sito di progetto:
https://stratagem-cost.eu/
Starting date:
Year: 2018 Length in months: 48
PIN1 targeted therapy in high grade serous ovarian cancer patients
Funding body:
AIRC
Type:
Altri finanziamenti per progetti di ricerca
Role in the project:
LD
Starting date:
Year: 2020 Length in months: 60
PREDIzione Tumori Tiroidei
Funding body:
Regione Friuli Venezia Giulia
Type:
POR FESR (2014-2020)
Role in the project:
PT
Starting date:
Year: 2018 Length in months: 36
Produzione di fattori di crescita in pianta per la produzione di proteine alternative
Funding body:
POR-FSE Veneto
Type:
POR FSE (2014-2020)
Role in the project:
LD
Starting date:
Year: 2023 Length in months: 12
Sensori elettrochimici e kit biomolecolari per l'analisi di contaminanti emergenti in prodotti agroalimentari
Funding body:
FSE
Type:
POR FESR (2014-2020)
Role in the project:
LD
Starting date:
Year: 2017 Length in months: 12
Sviluppo di procedure standardizzate per la valutazione di microplastiche in prodotti agroalimentari
Funding body:
Regione Veneto
Type:
POR FESR (2014-2020)
Role in the project:
LD
Starting date:
Year: 2020 Length in months: 15
TIGER
Funding body:
Europa
Type:
Interreg IV Spazio Alpino
Role in the project:
PT
Starting date:
Year: 2024 Length in months: 36
Tumoroids as new REAl Time therapy for High Grade Serous Epithelial Ovarian Cancer patients
Funding body:
Università Ca' Foscari
Type:
Progetti di Ateneo
Role in the project:
LD
Starting date:
Year: 2019 Length in months: 24

Publication highlights

Botter, Eleonora; Lauteri, Valentina; Rubbi, Alessandro; Orian, Laura; Forner, Matteo; Gandin, Valentina; Demitri, Nicola; Canzonieri, Vincenzo; Rizzolio, Flavio; Cavarzerani, Enrico; Visentin, Fabiano; Scattolin, Thomas Insertion of SnCl2 into the Pd–Cl bond: mechanistic elucidation and antitumor evaluation of trichlorostannyl palladium–NHC allyl complexes in ovarian cancer models in DALTON TRANSACTIONS, vol. 55, pp. 6351-6372 (ISSN 1477-9226)
DOI 2026, Journal Article - ARCA card: 10278/5116932


Saorin, Gloria; Mauceri, Matteo; Caligiuri, Isabella; Kamensek, Urska; Kranjc Brezar, Simona; Corona, Giuseppe; Repetto, Ombretta; Perin, Tiziana; Grassi, Gabriele; Granchi, Carlotta; Tuccinardi, Tiziano; Cemazar, Maja; Canzonieri, Vincenzo; Adeel, Muhammad; Rizzolio, Flavio Nanoformulation of a Pin1 inhibitor potentiates the efficacy of liposomal doxorubicin in second-line therapy for ovarian cancer in CANCER LETTERS, vol. 637, pp. 218128 (ISSN 0304-3835)
DOI 2026, Journal Article - ARCA card: 10278/5112410


Singh, Mamta; Yadav, Anubha; Singh, Umesh; Gupta, Rajat; Cavarzerani, Enrico; Canzonieri, Vincenzo; Negi, Deepraj; Dagar, Akansha; Sathyamoorthy, Bharathwaj; Rizzolio, Flavio; Kumar, Sushil; Baliyan, Ankur; Rani, Reshma; Kumar, Vinit Nature‐Inspired MYC Inhibitor Disrupts MYC‐Driven Glycolysis and Restricts Ovarian Tumor Growth in CHEMMEDCHEM, vol. 21 (ISSN 1860-7179)
DOI 2026, Journal Article - ARCA card: 10278/5112408


Tonon, Giovanni; Rafaniello, Anna; Mauceri, Matteo; Demitri, Nicola; Scattolin, Thomas; Rizzolio, Flavio; Visentin, Fabiano Palladium(0) and Juglone: a new alliance in the fight against ovarian cancer in DALTON TRANSACTIONS, vol. 55, pp. 445-459 (ISSN 1477-9226)
DOI 2026, Journal Article - ARCA card: 10278/5112409


Arnaut, Pierre; Pozsoni, Nestor Bracho; Bondar, Denys; Lippmann, Petra; Boschuk, Susanne; Semenyuta, Ivan; Bhandary, Subhrajyoti; Van Hecke, Kristof; Karpichev, Yevgen; Cavarzerani, Enrico; Canzonieri, Vincenzo; Rizzolio, Flavio; Scattolin, Thomas; Vougioukalakis, Georgios C.; Ott, Ingo; Tzouras, Nikolaos V.; Nolan, Steven P. A new generation of N-heterocyclic carbene (NHC) gold–selenolato complexes as potent anticancer agents: distinct synthetic routes and evaluation in 2D and 3D cancer models in CHEMICAL SCIENCE, vol. 16, pp. 17221-17231 (ISSN 2041-6520)
DOI 2025, Journal Article - ARCA card: 10278/5112407


List of publications

Curriculum vitae

Dr. Rizzolio is full professor in molecular biology at the Department of Molecular Sciences and Nanosystems at Ca' Foscari University. He obtained the specialization in Applied Genetics in 2004 at University of Pavia. During the period 2007- 2011, he worked at the Department of Biology of Temple University (Philadelphia, USA) as a Visiting Research Scholar. During this time, he completed the PhD program in oncology and genetics. On 1 February 2011, he received the title of Assistant Professor at Temple University.

The research activity of Dr. Rizzolio can be summarized in three periods.  First phase (2000-2007): his scientific career began in 2000 with the thesis focused on the molecular and genetic analysis of two genes mapped on chromosome X candidate Premature ovarian failure (POF). It was also studied the effects of the interaction of the X and autosome chromosomes on the expression of flanking genes in POF patients with X-autosome balanced translocation. During this scientific period, he improved many basic techniques of molecular biology and genetics. Second stage (2007-2011): during the PhD program, he studied the role of may proteins involved in cell cycle control of cancer cells. In particular, it has been investigated the role of Retinoblastoma family of proteins and Pin1. During this scientific step, he improved many basic techniques of molecular/cellular biology and animal models. Third phase (2011-2016): Development of biocompatible nanodrugs in oncology. At the Centro di Riferimento Oncologico and now at Ca' Foscari University, he is working on the development of new nanodrugs based on biocompatible materials (DNA, Liposomes, exosomes).   He published more than 200 research papers and he is a member of the Editorial Advisory Board of the following journals: Nanomedicine & Nanoscience Research and Frontiers in Nanoscience. He is the founder and CEO of BioFuture Medicine.