Alessandro Angelini was born in Verona (Italy) on 6 April 1978. He received his M.Sc. degree, “summa cum laude”, in Biotechnology from the University of Padua in 2004.
Alessandro Angelini earned his Ph.D. degree in Biochemistry and Biotechnology under the supervision of Prof. Dr. Giuseppe Zanotti at the University of Padua in 2008. His thesis focused on the structural characterization of proteins of the type IV secretion system of the human pathogen Helicobacter pylori. During his doctoral studies, Alessandro Angelini was a visiting scientist in the laboratories of Dr. Laurent Terradot at the European Synchrotron Radiation Facility (ESRF) and Dr. Darren Hart at the European Molecular Biology Laboratory (EMBL) in Grenoble, France. For his research abroad, he was awarded the title of “Doctor Europaeus”.
From 2008 to 2011, Alessandro Angelini was a postdoctoral researcher at the laboratory of Prof. Dr. Christian Heinis at the École Polytechnique Fédérale de Lausanne (EPFL). During this period, he applied phage display technology to develop innovative bicyclic peptide-based therapeutics.
In 2012, Alessandro Angelini joined the laboratory of Prof. Dr. Karl Dane Wittrup at the Massachusetts Institute of Technology (MIT) as a SNSF advanced researcher. Throughout this period, he applied yeast display technology to engineer broadly crossreactive antibodies with therapeutic efficacy in a mouse model for rheumatoid arthritis.
Since 2017, Alessandro Angelini is a tenure-track researcher B-type (RTD-B) at the Department of Molecular Science and Nanosystems of the Ca’ Foscari University of Venice. His research is primarily focused on the development of peptides and proteins with a novel mechanism of action that have the potential to overcome the limitations of current therapeutic and diagnostic applications.
Alessandro Angelini has published more than twenty articles in international peer-reviewed journals, two patent applications and three book chapters. He deposited the atomic coordinates of fourteen crystal structures at the Protein Data Bank.
Alessandro Angelini is a member of the Protein Society, the Italian Society of Biochemistry and Molecular Biology (SIB), and the Italian Network for Tumor Biotherapy (NIBIT).
Alessandro Angelini is the recipient of the Engineer Aldo Gini Foundation Fellowship for Undergraduate Student (2006), the Swiss National Science Foundation (SNSF) Fellowship for Advanced Researcher (2012-2014) and the Ludwig Foundation for Cancer Research Postdoctoral Fellowship (2014-2015).